A Descriptive Study on Patients of Papulosquamous Lesion at Tertiary Care Institute S. D. Chavhan 1* , S. V. Mahajan 2 and A. J. Vankudre 3 1 MD, PG Resident, Department of Pathology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik, India; drbhadanesapana@gmail.com 2 Professor and Head of Department, Department of Pathology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik, India; drmahajansuresh@yahoo.co.in 3 Assistant Professor, Department of Community Medicine, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik, India; easyashok@gmail.com Abstract Background: Papulosquamous lesions of the skin are encountered with considerable frequency. There is overlap of both clinical pattern and distribution of papulosquamous skin disorders, which often makes clinical diagnosis difficult. However, some of the histopathological features are specific and characteristic for each entity. Hence, combination of proper clinical observation and histopathological study will give a conclusive diagnosis. Material & Methods: A cross sectional study was done in department of pathology in which after satisfying inclusion criteria all papulosquamous lesion patients irrespec- tive of age & gender were included in study in defined period. A brief history and dermatological examination was carried out. Skin biopsies taken were fixed in 10% formalin and subjected for tissue processing. The processed tissue was embed- ded in paraffin to obtain five-micron thin sections. The sections were stained with routine hematoxylin and eosin stain, followed by microscopic examination. Result: Out of 61 patients of papulosquamous lesion most common diagnosis was Lichen planus, (57.37 %) followed by Psoriasis (32.78 %). Commonest age group reporting Lichen planus & Psoriasis was 21–40 yrs. Male preponderance was noted in all papulosquamous lesion patients. Histological features commonly seen were hyperkeratosis, parakeratosis in both Lichen planus & Psoriasis patients. *Author for correspondence MVP Journal of Medical Sciences, Vol 1(1), 30–35, January 2014 Keywords: Papulosquamous, Clinical, Histologiscal, Histological Features. 1. Introduction Te Papulosquamous skin disorders are a heterogeneous group of disorders that comprise the largest group of diseases seen by dermatologist. Te nosology of these dis- orders is based on a descriptive morphology of clinical lesions characterized by scaly papules and plaques 1 . Tese diseases assume considerable importance because of their frequency of occurrence. Te papulosquamous disorders are complex to diag- nose, as they are difcult to identify and may resemble a similar disorder of the group. Hence, these disorders are commonly misdiagnosed 2 . Histomorphologic diagnosis is important for separation of these disorders because the treatment and prognosis for each tends to be disease specifc. 2. Materials and Methods 2.1 Source of Data Te present study is a histopathological study of papu- losquamous disorders of skin, which includes 61 cases of clinically diagnosed papulosquamous eruptions, having attended the Department of Dermatology, Venerology, and Leprosy.