Global J Res. Med. Plants & Indigen. Med. | Volume 4, Issue 9 | September 2015 | 193–202 Global Journal of Research on Medicinal Plants & Indigenous Medicine || GJRMI || ISSN 2277-4289 | www.gjrmi.com | International, Peer reviewed, Open access, Monthly Online Journal CO-ADMINISTRATION OF ETHANOLIC LEAF EXTRACT OF MORINGA OLEIFERA AND METFORMIN REVERSES POLYPHAGIA, POLYDIPSIA AND STABILIZES BODY WEIGHT IN ALLOXAN- INDUCED DIABETIC RATS IDAKWOJI Precious Adejoh 1 *, AKUBA Ojochegbe Barnabas 2 , ELAH Onyeche Sarah 3 1 Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria 2 Department of Science Laboratory Technology, Kogi State Polytechnic, Lokoja 3 Department of Chemical Sciences, Faculty of Natural and Applied Sciences, University of Mkar, Mkar- Nigeria *Corresponding Author: E-Mail: sirprecious@yahoo.com ; Phone: (+234) 8077039243 Received: 10/07/2015; Revised: 20/08/2015; Accepted: 10/09/2015 ABSTRACT This study examined the effect of Ethanol extract of Moringa oleifera (MOE) leaves and metformin co-administration on the glucose levels, bodyweight, food and water intake of diabetic Wistar rats. Diabetes was induced in rats by administration of 150 mg alloxan/kg body weight intraperitoneally. Six groups of diabetic rats and one group of normoglycaemic rats (n = 6) were used for the study. Groups I and II served as non-diabetic and diabetic controls respectively. Groups III and IV received 400 and 800 mg MOE /kg respectively, groups V and VI received the same doses of MOE respectively but co-administered with metformin (150 mg/kg) and group VII received metformin (150 mg/kg) alone. Daily food and water intake, weekly body weight change and fasting blood glucose levels were estimated for 28 days. MOE (400 mg/kg)/ metformin and MOE (800 mg/kg)/ metformin administration showed significant reduction in FBS (p< 0.001) on days 7, 14, 21 and 28, food intake and water intake (p< 0.001) in weeks 2, 3 and 4 but no significant difference was observed in the body weight of treated rats when compared to diabetic control. It was concluded that the extract and metformin co-use may be useful in ameliorating symptoms of diabetes. KEY WORDS: Diabetes mellitus, Metformin, Moringa oleifera, Polydipsia, Polyphagia Research article Cite this article: IDAKWOJI Precious Adejoh, AKUBA Ojochegbe Barnabas, ELAH Onyeche Sarah (2015), CO-ADMINISTRATION OF ETHANOLIC LEAF EXTRACT OF MORINGA OLEIFERA AND METFORMIN REVERSES POLYPHAGIA, POLYDIPSIA AND STABILIZES BODY WEIGHT IN ALLOXAN- INDUCED DIABETIC RATS, Global J Res. Med. Plants & Indigen. Med. , Volume 4(9): 182–192