www.wjpps.com Vol 3, Issue 8, 2014. 1942 Valentina et al. World Journal of Pharmacy and Pharmaceutical Sciences PSORIASIS INFLUENCE ON THE PATIENTS’ QUALITY OF LIFE Valentina B. Petkova 1 , Milen V. Dimitrov 1 , Irina N. Nikolova 1 , Christina Ch. Voycheva, Velisslava G. Valchanova MA 1 , Kalina G. Andreevska 2 1 Faculty of Pharmacy, Medical University – Sofia, Bulgaria 2 Faculty of Pharmacy, Medical University – Plovdiv, Bulgaria. ABSTRACT Background Psoriasis influences patient's lives, affecting them physically, psychologically and socially. Their quality of life is similar to that of other major medical diseases such as cancer, arthritis, hypertension, heart disease, diabetes and depression. The objective of this study was to evaluate QOL in psoriasis patients before and after treatment with extemporaneous formulation. Methods: The patient’s self-assessment Koo-Menter Psoriasis Instrument (A part) is applied to 22 patients suffering from different stage of psoriasis. With 0 is indicated the absolute absence of a problem while with 10 – “very much” availability. All data were processed through SPSS 20.0 software. Chi-square test and t test were used as data analysis. Results: 22 patients were enrolled in the study. The correlation analysis of PQOL1 and PQOL2 and sex, age and duration shows that there is no significant correlation between the patients quality of life and their sex and age. But there is significant correlation between PQOL1 and the duration of the disease., Conclusions: The study showed there is improvement in QOL in psoriasis patients before and after treatment with the extemporaneous formulation. Duration of disease can be considered as a possible mediator of impact on QOL. Key words: psoriasis, quality of life, dermatology INTRODUCTION According to NORD (National Organization for Rare Disorders), psoriasis can be classified as a rare inflammatory chronic recurrent skin disease. 125 million people worldwide - 2 to 3 WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 2.786 V Vo ol l u um me e 3 3, , I Is ss su ue e 8 8, , 1 19 94 42 2- - 1 19 94 48 8. . R Re es se ea ar rc ch h A Ar rt ti i c cl l e e I IS SS SN N 2278 – 4357 Article Received on 15 May 2014, Revised on 12 June 2014, Accepted on 26 July 2014 *Correspondence for Author Professor Dr. Valentina Petkova Faculty of Pharmacy, Medical University – Sofia, Bulgaria