Case Report Thyroid, Renal, and Breast Carcinomas, Chondrosarcoma, Colon Adenomas, and Ganglioneuroma: A New Cancer Syndrome, FAP, or Just Coincidence Ihab Shafek Atta 1 and Fahd Nasser AlQahtani 2 1 Department of Pathology, Faculty of Medicine, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt 2 Department of Radiology, Faculty of Medicine, Al-Baha University, Saudi Arabia Correspondence should be addressed to Ihab Shafek Atta; attaihab@yahoo.com Received 30 November 2015; Revised 8 February 2016; Accepted 18 February 2016 Academic Editor: Mark E. Shafrey Copyright © 2016 I. S. Atta and F. N. AlQahtani. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We are presenting a case associated with papillary thyroid carcinoma, renal cell carcinoma, invasive mammary carcinoma, chondrosarcoma, benign ganglioneuroma, and numerous colon adenomas. Te patient had a family history of colon cancer, kidney and bladder cancers, lung cancer, thyroid cancer, leukemia, and throat and mouth cancers. She was diagnosed with colonic villous adenoma at the age of 41 followed by thyroid, renal, and breast cancers and chondrosarcoma at the ages of 48, 64, 71, and 74, respectively. Additionally, we included a table with the most common familial cancer syndromes with one or more benign or malignant tumors diagnosed in our case, namely, FAP, HNPCC, Cowden, Peutz-Jeghers, renal cancer, tuberous sclerosis, VHL, breast/other, breast/ovarian, Carney, Werner’s, Bloom, Li-Fraumeni, xeroderma pigmentosum, ataxia- telangiectasia, osteochondromatosis, retinoblastoma, and MEN2A. 1. Introduction A cancer diagnosed at young age, multifocal or bilateral in paired organs, more than one primary unrelated cancer, fam- ily history of cancer, or congenital anomalies will make the diagnosis of family cancers syndromes a high possibility [1]. Familial adenomatous polyposis (FAP) is a syndrome with mutations in APC gene on 5q21–q22. Diagnosis of FAP is suspected clinically in the presence of hundreds of colorectal polyps running in certain families but mutational analysis study is the golden test for diagnosis. Colon cancer, follicular cancer, papillary thyroid cancer, gastric cancer, and medul- loblastomas (Turcot syndrome) are the most common malig- nant tumors [2, 3]. Associated benign lesions are colonic, gastric, and duodenal polyps [4, 5]. Hereditary Nonpolyposis Colon Cancer (HNPCC) is another syndrome with reported mutations in the mismatch repair gene (MMR) complexes that include several mutations as hMLH1 at 3p21.3, hMSH2 at 2p22–p21, hPMS1 at 2q31–q33, hPMS2 at 7p22, and hMSH6 at 2p16 [6]. Diagnosis depends on a family pedigree with colon cancer diagnosed before the age of 50 with no familial ade- nomatous polyposis detected [6]. Associated malignant neo- plasms are colorectal, endometrial, ovarian, and transitional cell cancers of the urinary system, gastric cancer, small bowel cancer, pancreas cancer, hepatobiliary carcinoma, sebaceous carcinoma, glioblastoma multiforme, and breast cancer [2, 7]. Associated benign neoplasms are colonic adenomas, keratoacanthomas, sebaceous adenomas, and epitheliomas. Cowden syndrome is reported with mutations in PTEN gene at 10q23 [8–10]. Clinical diagnosis is based on mucocuta- neous lesions, intestinal hamartomas, craniomegaly, coarse, dark hair, rapid overgrowth of breasts, and cerebellar glial mass leading to altered gait and seizures (Lhermitte-Duclos disease). Associated malignant tumors are breast, thyroid, colon, kidney, ovary, endometrium, and lung carcinomas, melanoma, Merkel cell skin cancer, and retinal glioma. Asso- ciated benign lesions are skin verruci of the face and limbs, hyperkeratotic papules of the gingiva and buccal mucosa, facial trichilemmomas, oral mucosal fbromas, hyperkerato- sis of hand and foot, hamartomatous polyps of stomach, small Hindawi Publishing Corporation Case Reports in Medicine Volume 2016, Article ID 2928084, 5 pages http://dx.doi.org/10.1155/2016/2928084