1 Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations Authors: Jihong Li, MD a † , Yoshiyuki Fukase, PhD b† , Yi Shang, PhD c† , Wei Zou, PhD d† , José M. Muñoz-Félix e† , Lorena Buitrago, PhD a† , Johannes van Agthoven, PhD f , Yixiao Zhang, PhD g , Ryoma Hara, PhD b , Yuta Tanaka, PhD b , Rei Okamoto, PhD b , Takeshi Yasui, PhD b , Takashi Nakahata, PhD b , Toshihiro Imaeda, PhD b , Kazuyoshi Aso, PhD b , Yuchen Zhou, PhD c , Charles Locuson, PhD h , Dragana Nesic, PhD a , Mark Duggan, PhD i , Junichi Takagi, PhD j , Roger D. Vaughan, PhD k , Thomas Walz, PhD g , Kairbaan Hodivala-Dilke, PhD e , Steven L. Teitelbaum, MD d , M. Amin Arnaout, MD f , Marta Filizola, PhD c , Michael A. Foley, PhD b , and Barry S. Coller, MD a,* †Contributed equally a Allen and Frances Adler Laboratory of Blood and Vascular Biology, Rockefeller University, 1230 York Avenue, New York, NY 10065; b Tri-Institutional Therapeutics Discovery Institute, 413 East 69 Street, New York, NY 10021; c Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1677, New York, NY 10029-6574; d Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St. Louis, MO 63110; e Adhesion and Angiogenesis Laboratory, Centre for Tumour Biology, Barts Cancer Institute—a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK; f Leukocyte Biology and Inflammation and Structural Biology Programs, Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, 149 13 th Street, Charlestown, MA, 02129; g Laboratory of Molecular Electron Microscopy, Rockefeller University, 1230 York Avenue, New York, NY 10065; h Agios Pharmaceuticals, 88 Sidney Street, Cambridge, MA 02139-4169; i LifeSci Consulting, LLC, 18243 SE Ridgeview Drive, Tequesta, FL 33469; j Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan. k Rockefeller University Center for Clinical and Translational Science, Rockefeller University, 1230 York Avenue, New York, NY 10065 * To whom correspondence should be addressed: Email: collerb@rockefeller.edu Keywords: Integrin, αVβ3, Osteoclast, Angiogenesis certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint (which was not this version posted May 24, 2019. . https://doi.org/10.1101/620765 doi: bioRxiv preprint