Siddha Papers 2020 (15) (2) Thomas M. Walter et al, Siddha Papers 2020 (15) (2) RESEARCH ARTICLE www.siddhapapers.org Effect of Nilavembu kudineer in the Prevention and Management of COVID – 19 by inhibiting ACE2 Receptor Thomas M.Walter # , C. Samuel Justinraj*, V.S. Nandini* # Associate Professor, Dept. of Medicine, Govt. Siddha Medical College, Palayamkottai, T.N. India. dr.thomaswalter@gmail.com * CRRI, Govt. Siddha Medical College, Palayamkottai, T.N. India. Keywords Nilavembu Kudineer, COVID-19, NCoV-19, Siddha Medicine, Anti-viral Herbs, ACE2 enzyme receptor, In-silico Molecular Docking analysis. Background Novel Corona virus is making its Worldwide propagation in a very fast phase. It is now essential to discover the drugs that are useful in the prevention and management of NCoV-19. Many traditional Herbs and Poly Herbal synergistic formulations are useful in the prophylaxis of various types of Viruses. In Siddha system of medicine, there are various medicines used for antiviral therapies. Nilavembu kudineer is a very remarkable medicine which is already recognized by the Government of Tamilnadu during the eradication program of Dengue and Chikungunya viruses. To prove safety and efficacy of a traditional medicine, Reverse pharmacology method is recognized globally. Reverse pharmacology is confirming the safety and efficacy of a medicine which is already in clinical practice by going back in the steps of pharmacological screening and drug development. The ultimate aim of the Reverse pharmacological research is to find the mechanism of action by a drug against a disease. For Nilavembu kudineer (Mentioned in the Siddha text Siddha Vaithiya Thirattu), clinical documentations and various pre-clinical studies on its safety and efficacy are already done. In this study, we have done the In-silico Molecular Docking Analysis of the Bio-active compounds found in the aqueous extract of Nilavembu kudineer chooranam against the ACE2 enzyme receptor which is the route of entry in the pathogenesis of Novel corona