Archive of SID ﭼﺸﻢ ﻣﺠﻠﻪ ﺑﻴﻨﺎ ﭘﺰﺷﻜﻲ- ﺩﻭﺭﻩ١٢ - ﺷﻤﺎﺭﻩ٤ ) ﺗﺎﺑﺴﺘﺎﻥ١٣٨٦ ( ٤٥٢ Cataract Etiology in Children Less than 3 Years of Age at Khalili Hospital, Shiraz-Iran Eghtedari M, MD; Khoshamadi A, MD; Motamedifar M, PhD, Hadi N, MSc, Salouti R, MD; Talebnejad MR, MD Purpose: To evaluate the etiology of cataracts in children less than 3 years of age particularly the association of rubella virus infection and galactosuria with congenital cataracts at Khalili Hospital, Shiraz-Iran from 2003 to 2006. Methods: This prospective study included 46 patients less than 3 years undergoing lensectomy for the management of significant cataracts. Lens aspirate specimens were obtained from some cases. Serum samples for detection of anti-rubella IgM and IgG antibodies and urine samples for detection of galactose were also obtained. Results: Out of 46 patients, 78.3% had congenital cataracts and 21.7% had traumatic cataracts. Patients with congenital cataracts were male in 45% and female in 55% with mean age of 5.12±5.23 months at the time of diagnosis. In the congenital cataract group, 2.8% had history of failure to thrive and 16.7% had low birth weight; 80.6% had bilateral and 19.4% had unilateral cataracts; 77.8% had isolated cataracts, 16.7% were associated with other ocular disorders and 5.6% were associated with systemic diseases; 11.1% had family history of congenital cataracts and 10.5% had galactosuria. Rubella virus was isolated from one (5.3%) of 19 cultured lens aspirates. No cases had anti-rubella IgM antibody. Conclusion: Congenital cataract is the most common type of cataracts in children under age 3 years in our area and most of them are idiopathic. The prevalence of rubella induced cataract in our country is less than developing countries but more than developed countries. • Bina J Ophthalmol 2007; 12 (4): 452-457. ﻋﻠﻞ آب ﻣﺮوارﻳﺪ ﺟﺮ ﻫﺎي اﺣﻲ ﺷﺪه زﻳﺮ ﻛﻮدﻛﺎن در ﺳﻪ ﺳﺎل در ﺷﻴﺮاز ﺧﻠﻴﻠﻲ ﺑﻴﻤﺎرﺳﺘﺎن اﻗﺘﺪاري ﻣﻌﺼﻮﻣﻪ دآﺘﺮ ١ ﺧﻮش ﻋﻠﻲ دآﺘﺮ، ﺁﻣﺪي ٢ ﻣﻌﺘﻤﺪي دآﺘﺮﻣﺤﻤﺪ، ﻓﺮ ٣ هﺎدي ﻧﻬﺎل، ۴ ﺻﻠﻮﺗﻲ راﻣﻴﻦ دآﺘﺮ، ١ ﻃﺎﻟﺐ ﻣﺤﻤﺪرﺿﺎ دآﺘﺮ و ﻧﮋاد ١ ﻫﺪﻑ: ﺁﺏ ﻋﻠﻞ ﺗﻌﻴﻴﻦ ﮐﻮﺩﮐﺎﻥ ﺩﺭ ﻣﺮﻭﺍﺭﻳﺪ ﺯﻳﺮ۳ ﺳﺎ ﻟﻪ ﺗﺤﺖ ﮐﻪ ﺍﻱ ﻟﻨﺰﮐﺘﻮﻣﻲ ﮔﺮﻓﺘﻨﺪ ﻗﺮﺍﺭ ﺍ ﻭ ﺭﺯﻳﺎﺑﻲ ﻭﻳـﺮﻭﺱ ﻋﻔﻮﻧـﺖ ﺭﺍﺑﻄـﻪ ﺳﺮﺧﺠﻪ ﺑﺎ ﮔﺎﻻﻛﺘﻮﺯﻣﻲ ﺑﻴﻤﺎﺭﻱ ﻭ ﺁﺏ ﻣﺮﻭﺍﺭﻳﺪ ﻣﺎﺩﺭﺯﺍﺩﻱ. ﭘﮋﻭﻫﺶ ﺭﻭﺵ: ﺑ ﻣﻄﺎﻟﻌﻪ ﻪ ﺁﻳﻨﺪﻩ ﺻﻮﺭﺕ ﺭﻭﻱ ﺑﺮ ﻧﮕﺮ۴۶ ﺑﻴﻤﺎﺭ ﺯﻳﺮ۳ ﺳﺎﻟﻪ ﺍﻱ ﭘﺬﻳﺮﻓﺖ ﺍﻧﺠﺎﻡ ﺑـﻪ ﮐـﻪ ﻋﻠـﺖ ﺁﺏ ﻣﺮﻭﺍﺭﻳـﺪ ﻗﺎﺑـﻞ ﺳﺎﻝ ﻃﻲ ﺗﻮﺟﻪ ﻫﺎﻱ۸۴ - ۱۳۸۲ ﺷﻴﺮﺍﺯ ﺧﻠﻴﻠﻲ ﺑﻴﻤﺎﺭﺳﺘﺎﻥ ﺩﺭ ﻟﻨﺰﻛﺘﻮﻣﻲ ﻣﻲ ﺷﺪﻧﺪ. ﺗﻌﺪﺍﺩﻱ ﺍﺯ ﺑﻪ ﻣﺒﺘﻼ ﺑﻴﻤﺎﺭﺍﻥ ﺍﺯ ﺁﺏ ﻣﺮﻭﺍﺭﻳـﺪ ﻣﺎﺩﺭﺯﺍﺩﻱ، ﺁﺳﭙﻴﺮﻩ ﻧﻤﻮﻧﻪ ﻋﺪﺳﻲ ﺍﻧﺠﺎﻡ ﺟﻬﺖ ﺁﺯﻣﺎﻳﺶ ﻏﻴﺮﻣﺴﺘﻘﻴﻢ ﺍﻳﻤﻮﻧﻮﻓﻠﻮﺭﺳﺎﻧﺲ ﺳـﺮﺧﺠﻪ ﻭﻳـﺮﻭﺱ ﻧﻈـﺮ ﺍﺯ ﺳـﺮﻡ ﻧﻤﻮﻧـﻪ، ﺍﻧﺪﺍﺯﻩ ﺟﻬﺖ ﺑﻴﻤﺎﺭ ﺁﻧﺘﻲ ﮔﻴﺮﻱ ﺑﺎﺩﻱIgM ﻭIgG ﺿﺪ ﺳﺮﺧﺠﻪ ﺍﻧﺪﺍﺯﻩ ﺟﻬﺖ ﺑﻴﻤﺎﺭ ﺍﺩﺭﺍﺭ ﻧﻤﻮﻧﻪ ﻭ ﮔﺎﻻﻛﺘﻮﺯ ﮔﻴﺮﻱ ﺑﺮﺭﺳﻲ ﮔﺮﺩﻳﺪ. ﻳﺎﻓﺘﻪ ﻫﺎ: ﻣﺠ ﺍﺯ ﻤﻮﻉ۴۶ ﺑﻴﻤﺎﺭ،۳ / ۷۸ ﺩﺭﺻﺪ ﺁﺏ ﻣﺮﻭﺍﺭﻳﺪ ﻣﺎﺩﺭﺯﺍﺩﻱ ﻭ۷ / ۲۱ ﺁﺏ ﺩﺭﺻﺪ ﺿﺮﺑﻪ ﻣﺮﻭﺍﺭﻳﺪ ﺍﻱ ﺩﺍﺷﺘﻨﺪ. ﺑﻴﻤﺎﺭﺍﻥ ﻣﺒﺘﻼ ﺑﻪ ﺁﺏ ﻣﺮﻭﺍﺭﻳﺪ ﻣﺎﺩﺭﺯﺍﺩﻱ،۴۵ ﺩﺭﺻﺪ ﻭ ﻣﺬﻛﺮ۵۵ ﺩﺭﺻﺪ ﻣ ﻮ ﻧـﺚ ﺑـﺎ ﺳـﻦ ﻣﺘﻮﺳـﻂ۲۳ / ۵ ± ۱۲ / ۵ ﺯﻣـﺎﻥ ﺩﺭ ﻣـﺎﻫﮕﻲ ﺗـﺸﺨﻴﺺ ﺁﺏ ﻣﺮﻭﺍﺭﻳﺪ ﺑﻮﺩ ﻧﺪ. ﺑﻴﻤﺎﺭﺍﻥ ﺍﺧﻴﺮ ﮔﺮﻭﻩ ﺩﺭ۸ / ۲ ﺩﺭﺻﺪ ﻣﻮﺍﺭﺩ ﺳﺎﺑﻘﻪ ﻭ ﻋﺪﻡ ﺯﻥ ﮔﻴﺮﻱ ﻭ ﺩﺭ۷ / ۱۶ ﻣﻮﺍﺭﺩ ﺩﺭﺻﺪ ﺳﺎﺑﻘﻪ ﭘـﺎﻳﻴﻦ ﻭﺯﻥ ﺗﻮﻟﺪ ﺩﺍﺷﺘﻨﺪ. ﺁﺏ ﻣﺮﻭﺍﺭﻳﺪ ﮔﺮﻭﻩ، ﺍﻳﻦ ﺩﺭ ﺩﺭ۶ / ۸۰ ﺩﺭﺻﺪ ﻣﻮﺍﺭﺩ ﻭ ﺩﻭﻃﺮﻓـﻪ ﺩﺭ۴ / ۱۹ ﻣـﻮﺍﺭﺩ ﺩﺭﺻـﺪ ﻳـﻚ ﻃﺮﻓـﻪ ﺑـﻮﺩ؛ ﺩﺭ۸ / ۷۷ www.SID.ir