Open Peer Review Discuss this article (0) Comments CASE REPORT Case Report: Recurrent hypokalemic periodic paralysis associated with distal renal tubular acidosis (type 1) and hypothyroidism secondary to thyroiditis [version 1; referees: 1 approved] E. Dante Meregildo-Rodríguez , Virgilio E. Failoc-Rojas 1,2 Servicio de Medicina Interna y emergencia, Hospital Regional Lambayeque, Lambayeque, Peru Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Peru Abstract Hypokalemic periodic paralysis (HypoKPP) is characterized by Background: transient episodes of flaccid muscle weakness. We describe the case of a teenaged boy with HypoKPP and hyperthyroidism due to Hashimoto's thyroiditis with initial manifestation of renal tubular acidosis. This combination is rare and little described previously in men. : A 17-year-old boy was admitted after three days of Case presentation muscular weakness and paresthesia in the lower limbs with an ascending evolution, leading to prostration. Decreased strength was found in the lower limbs without a defined sensory level, reduced patellar and ankle reflexes. Positive antithyroid antibodies were found. He received hydration treatment, IV potassium and levothyroxine, with which there was a clinical improvement. Other examinations led to the diagnosis of type 1 renal tubular acidosis. : HypoKPP is a rare disorder characterized by acute episodes of Conclusion muscle weakness. Type 1 renal tubular acidosis can occur as a consequence of thyroiditis, which is explained by the loss of potassium. This combination is unusually rare, and has not been described before in men. The etiopathogenesis of the disease as well as a dynamic explanation of what happened with the patient are discussed in this report. Keywords hypokalemic periodic paralysis; distal renal tubular acidosis (type 1); hypothyroidism; Hashimoto Disease 1 1,2 1 2 Referee Status: Invited Referees version 1 published 30 Jul 2018 1 report , Instituto de Cristian Díaz-Vélez Investigación, Facultad de Medicina Humana, Universidad de San Martín de Porres, Peru Hospital Nacional Almanzor Aguinaga Asenjo EsSalud, Peru 1 30 Jul 2018, :1154 ( First published: 7 ) https://doi.org/10.12688/f1000research.15662.1 30 Jul 2018, :1154 ( Latest published: 7 ) https://doi.org/10.12688/f1000research.15662.1 v1 Page 1 of 7 F1000Research 2018, 7:1154 Last updated: 31 OCT 2018