Review Energizing the CO 2 utilization by chemo-enzymatic approaches and potentiality of carbonic anhydrases: A review Tanvi Sharma a , Swati Sharma b , Hesam Kamyab c , Ashok Kumar a, * a Department of Biotechnology and Bioinformatics, Jaypee University of InformationTechnology, Waknaghat, Solan, 173 234, India b University Institute of Biotechnology (UIBT), Chandigarh University, Mohali, Punjab,140413, India c Department of Engineering, Razak Faculty of Technology and Informatics, Universiti Teknologi Malaysia, 54100, Kuala Lumpur, Malaysia article info Article history: Received 30 May 2019 Received in revised form 24 October 2019 Accepted 1 November 2019 Available online 4 November 2019 Handling Editor: Prof. Jiri Jaromir Klemes Keywords: CO 2 Capture Global warming Carbonic anhydrase Immobilization CaCO 3 abstract During the last few decades, enormous emissions of greenhouse gases (GHGs) into the atmosphere by human activities, lead to global warming. Thus, it becomes essential to prevent the excessive emission or to develop new technologies to avoid successive accumulation of CO 2 . Biological systems in nature have the capability to x the atmospheric CO 2 but in the urban and industrially developed areas where a rate of CO 2 emission is very high, the biological system cannot capture and utilize the whole CO 2. Various chemicals and synthetic materials with CO 2 absorbing property are not eco-friendly or these are very expensive. Carbonic anhydrase (CA) is the fastest known enzymes containing zinc in its active site, convert CO 2 to bicarbonate ions. It is one of a potent biological catalyst for CO 2 conversion. Thus, in order to reduce the level of CO 2 the biocatalytic properties of microbial CA can be exploited. Literature survey showed that, more than fty different microbial CAs have been explored for CO 2 sequestration. The major advantages of CA to sequester CO 2 are economic viability and carbonation of CO 2 at a low concentration. Despite the higher rate of catalysis, the stability of CA is a major challenge for its industrial application. These difculties have been partly solved by immobilizing the CA onto the bio-inspired surface, biochar, alginate, polyurethane foam and variety of nano-textured materials. A combination of enzyme and material which jointly capture and convert the CO 2 into either carbon-rich compound of economic value or reduced carbon derivatives will plausibly energize the CO 2 utilization. In this review, we discussed the recent advances in chemical and materials used for CO 2 capture, their advantages and limitations, uti- lization of microbial CA for CO 2 conversion, and its various applications. © 2019 Elsevier Ltd. All rights reserved. Contents 1. Introduction ........................................................................................................................ 2 2. Material collection and research analysis ................................................................................................ 2 3. Potential of microbial CA in CO 2 conversion .................................................. .......................................... 3 4. Catalytic mechanism and properties of CA .................................................. ........................................... 3 5. Chemicals and materials facilitating the CO 2 capture .................................................................................... 4 5.1. Chemicals for CO 2 capture ...................................................... ............................................... 4 5.2. Materials for CO 2 capture ....................................................................................................... 5 5.3. Hybrid systems for CO 2 capture .................................................... ............................................. 7 5.4. Natural/biological system for CO 2 capture ......................................................................................... 7 6. Modification methods of CA for improved CO 2 capture and conversion ..................................... ............................... 8 6.1. Directed evolution and protein engineering of CA .................................................................................. 8 6.2. CA as an immobilized biocatalyst for CO 2 conversion ............................................................................... 8 7. Analysis of different CO 2 capture technologies used in various countries .................................... ............................... 9 * Corresponding author. E-mail addresses: ashok.nadda@juit.ac.in, ashok.nadda09@gmail.com (A. Kumar). Contents lists available at ScienceDirect Journal of Cleaner Production journal homepage: www.elsevier.com/locate/jclepro https://doi.org/10.1016/j.jclepro.2019.119138 0959-6526/© 2019 Elsevier Ltd. All rights reserved. Journal of Cleaner Production 247 (2020) 119138