Jyothi et al. European Journal of Pharmaceutical and Medical Research www.ejpmr.com 317 DETERMINATION OF HEAVY METALS IN RICE SAMPLES BY ICP-MS IN AND AROUND TIRUPATI, CHITTOOR DISTRICT, ANDHRA PRADESH T. Vasantha and N.V.V. Jyothi* Department of Chemistry, Sri Venkateswara University, Titupati-517502, Andhrapradesh, India. Article Received on 13/03/2019 Article Revised on 03/04/2019 Article Accepted on 24/04/2019 INTRODUCTION Noxious elements are contemplated highly perilous to human being health and nonetheless, food security issue, undesirable health peril makes this one and they may origin acute or unrelieved poisoning. [1] Unrelieved exposure that has been allied with the induction of pathological changes and cause harm in central nervous system and organs, which is leading towards lower acumen quotient in brood. Metals contaminated soil unfavorably affects the intact ecosystem when these noxious heavy metals rove into groundwater or are taken up by plants and animals species, which may upshot in great peril to ecosystems owing to translocation and bioaccumulation. Due to the incidence of the urbanization and industrialization without ecological be concerned in meticulous, ecological demolition through noxious elements including Zn, Hg, Cr, Pb, Cd, Se, Cu, As and Co has augmented. Ecological pollutants are due to the accretion of heavy metals on a sober echelon in plants, and that are affecting the food crop excellence that are grown on polluted areas. [2,3] The transfer and bioaccumulation of heavy metals from soil to rice are of great magnitude to human being health, and rice cultivated in the contamination or elevated geological background of paddy soil can origin towards prospective healthiness tribulations. [4,5] Paddy rice (Oryza sativa L.) is the second mainly essential staple food for more than half of the world‟s inhabitants and also cultivated throughout all countries. [6] 30 percent of the nutritional vigor supply and 20 percent nutritional protein ingestion in Asia are provided by rice [7] (WHO/ FAO 2002). Though, it is illustrious that rice invariably contains noteworthy amounts of trace elements that accrue through the ecological food succession [8] (Watanabe et al. 1996). Metal contagion in paddy soils, grains and subsequent accretion in assorted parts of the rice plant are often reported from assorted countries. Solidum et al. said People who take rice as the staple food for every day energy prerequisite are potentially bare to noxious metals and metalloids by means of rice the staple food [9] (Solidum et al. 2012). As addressed by [10] Khaniki and Zazoli (2005), the rice grains although imminent as of non-polluted lands might SJIF Impact Factor 4.897 Research Article ISSN 2394-3211 EJPMR EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH www.ejpmr.com ejpmr, 2019,6(5), 317-324 ABSTRACT Asian countries are the chief in the production of rice clerical for regarding 90 percent of the world's production. More than 75percent of the world supply is absorb by population in Asian countries and consequently rice is of colossal magnitude to food defense of Asia. As a result the current research work proves the cause and modern status of heavy metal contamination of paddy lands in the surrounding Tirupati industrial areas and around chittoor district. A trouble free two stride microwave assisted digestion method was developed for the concurrent fortitude of seven elements of total heavy metals Cr, Ni, As, Se, Cd, Hg and Pb in rice samples by means of inductively coupled plasma mass spectrometry (ICP-MS). Approximately 0.3 grams of rice sample was originally digested by the use of a concoction of acids. The current revise was conducted to quantify the concentrations of heavy metals like chromium (Cr), nickel (Ni), arsenic (As), Selenium (Se), cadmium (Cd), Mercury (Hg) and lead (Pb) in locally cultivated rice and their probable human being health risks in the areas of surrounding Tirupati and around chittoor district is to be analyzed by means of the technique inductively coupled plasma mass spectroscopy (ICP-MS). Most importantly, a greater number of our explorations confirmed that the metal contents in rice grains were lower than the permissible limits which was confirmed by various standards, are Codex recommendations of joint Food and Agriculture Organization/ (WHO) World Health Organization Food Standards Program me and/or (FAO) food regulations imposed by the respective governments and compared with those obtained with the developed literature values. Thus it is harmless for consumption. From the present study, it is unambiguous that there is no prospective peril to the local inhabitants of these four sampling areas by consumption of rice. KEYWORDS: Heavy metals, Rice grains, Prospective peril effects, inductively coupled mass spectrometry (ICP- MS). *Corresponding Author: N.V.V. Jyothi Department of Chemistry, Sri Venkateswara University, Titupati-517502, Andhrapradesh, India.