1 A Strategic Research Agenda to the Biomarker-Based Diagnosis of Prodromal Alzheimer’s Disease Giovanni B. FRISONI, Departments of Psychiatry and Internal Medicine, University Hospitals and University of Geneva, Switzerland Marina BOCCARDI, LANVIE – Laboratory of Neuroimaging of Aging of Aging, Department of Psychiatry, University of Geneva, Switzerland; LANE - Laboratory of Alzheimer Neuroimaging & Epidemiology, IRCCS S. Giovanni di Dio - Fatebenefratelli, Brescia, Italy Frederik BARKHOF, VUMC, Amsterdam, The Netherlands, and Institutes of Neurology & Healthcare Engineering, UCL, London, UK and ESNR – European Society of Neuroradiology Kaj BLENNOW, Inst. of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, and Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; International Federation of Clinical Chemistry and Laboratory Medicine Working Group for CSF proteins (IFCC WG-CSF) Stefano CAPPA, IRCCS Fatebenefratelli, Brescia, Italy, and FENS – Federation of European Neuropsychological Societies Konstantinos CHIOTIS, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden Jean-Francois DÉMONET, Leenards Memory Center, Department of Clinical Neuroscience, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland Valentina GARIBOTTO, Nuclear Medicine and Molecular Imaging Division Geneva University and Geneva University Hospitals Panteleimon GIANNAKOPOULOS, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Geneva, Switzerland. Anton GIETL, University of Zurich, Institute for Regenerative Medicine-IREM, Switzerland Oskar HANSSON, Memory Clinic, Skåne University Hospital and the Clinical Memory Research unit, Lund University, Sweden Karl HERHOLZ, The University of Manchester Wolfson Molecular Imaging Centre, Manchester, UK Clifford R JACK Jr, Department of Radiology, Mayo Clinic, Rochester, MN, USA Flavio NOBILI, Department of Neuroscience (DINOGMI), University Genoa and IRCCS AOU San Martino-IST Genoa, Italy, and EANM – European Association of Nuclear Medicine Agneta NORDBERG, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Karolinska Institutet; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden Heather M. SNYDER, Alzheimer’s Association, Medical & Scientific Relations, Chicago, USA Mara TEN KATE, VU University Medical Center, Amsterdam, the Netherlands Andrea VARRONE, Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden