1 Detection of human disease conditions by single-cell morpho-rheological phenotyping of whole blood Nicole Toepfner 1,2,3 , Christoph Herold 1,4 , Oliver Otto 1,4,5 , Philipp Rosendahl 1,4 , Angela Jacobi 1 , Martin Kräter 6 , Julia Stächele 3 , Leonhard Menschner 3 , Maik Herbig 1 , Laura Ciuffreda 7 , Lisa Ranford-Cartwright 7 , Michal Grzybek 8,9 , Ünal Coskun 8,9 , Elisabeth Reithuber 10 , Geneviève Garriss 10 , Peter Mellroth 10 , Birgitta Henriques-Normark 10 , Nicola Tregay 2 , Meinolf Suttorp 3 , Martin Bornhäuser 6 , Edwin R. Chilvers 2 , Reinhard Berner 3 , Jochen Guck 1,* Affiliations 1 Center of Molecular and Cellular Bioengineering, Biotechnology Center, Technische Universität Dresden, Tatzberg 47/49, 01307 Dresden, Germany 2 Department of Medicine, University of Cambridge, Hills Road, Cambridge, CB20QQ, UK 3 Department of Pediatrics, University Clinic Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany 4 Zellmechanik Dresden GmbH, Tatzberg 47/49, 01307 Dresden, Germany 5 ZIK HIKE, Universität Greifswald, Fleischmannstr. 42-44, 17489 Greifswald 6 Department of Hematology and Oncology, University Clinic Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany 7 Institute of Infection, Immunity and Inflammation, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK 8 Paul Langerhans Institute Dresden of the Helmholtz Centre Munich at the University Clinic Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany 9 German Center for Diabetes Research (DZD e.V.), 85764 Neuherberg, Germany . CC-BY-NC-ND 4.0 International license not certified by peer review) is the author/funder. It is made available under a The copyright holder for this preprint (which was this version posted June 1, 2017. . https://doi.org/10.1101/145078 doi: bioRxiv preprint