Arch Clin Biomed Res 2021; 5 (4): 556-568 DOI: 10.26502/acbr.50170184 Archives of Clinical and Biomedical Research Vol. 5 No. 4 – August 2021. [ISSN 2572-9292]. 556 Case Report Severe Cryoglobulinemic Vasculopathy and Underlying Monoclonal Gammopathy: The Importance of Identifying and Targeting the Underlying Plasma Cell Clone in Diagnosis and Treatment Lisa B Leypoldt 1* , Susanne Ghandili 1 , Stefan W Schneider 2 , Christof Iking-Konert 3 , Carsten Bokemeyer 1 , Katja C Weisel 1 1 Department of Hematology, Oncology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 2 Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 3 Department of Nephrology, Section of Rheumatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany *Corresponding author: Dr. Lisa B Leypoldt, Department of Hematology, Oncology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany, Tel: +49 15222831701; Fax: +4940-7410-58581 Received: 11 June 2021; Accepted: 23 June 2021; Published: 21 July 2021 Citation: Lisa B Leypoldt, Susanne Ghandili, Stefan W Schneider, Christof Iking-Konert, Carsten Bokemeyer, Katja C Weisel. Severe Cryoglobulinemic Vasculopathy and Underlying Monoclonal Gammopathy: The Importance of Identifying and Targeting the Underlying Plasma Cell Clone in Diagnosis and Treatment. Archives of Clinical and Biomedical Research 5 (2021): 556-568. Abstract Cryoglobulinemia often occurs secondary to an underlying monoclonal gammopathy (MG). MG is a common finding in the elderly population with a prevalence of 5% in persons aged 70 years and older and can range from asymptomatic monoclonal gammopathy of unknown significance (MGUS) to symptomatic multiple myeloma (MM) for which treatment is clearly indicated. However, rare forms of MG lead to clinical symptoms and are summarized as monoclonal gammopathy of clinical significance