_____________________________________________________________________________________________________ *Corresponding author: E-mail: toussonehab@yahoo.com; Annual Research & Review in Biology 14(1): 1-8, 2017; Article no.ARRB.34318 ISSN: 2347-565X, NLM ID: 101632869 P53 Expression in Response to Equigan Induced Testicular Injury and Oxidative Stress in Male Rat and the Possible Prophylactic Effect of Star Anise Extracts Thanaa A. El-Masry 1 , Nora H. Al-Shaalan 2 , Ehab Tousson 3* , Kadreya El-Morshedy 1,4 and Areej Al-Ghadeer 5 1 Department of Pharmaceutical Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. 2 Department of Chemistry, Faculty of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. 3 Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt. 4 Department of Anatomy and Embryology, Faculty of Medicine, Tanta University, Tanta, Egypt. 5 Department of Pharmaceutical Practice, Faculty of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. Authors’ contributions This work was carried out in collaboration between all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/ARRB/2017/34318 Editor(s): (1) Bala Gopalan Unni, Assam Down Town University, Assam, India. (2) George Perry, University of Texas at San Antonio, USA. Reviewers: (1) Ngoc Huynh, Midwestern State University, USA. (2) Alicia García Falgueras, The Official College of Psychologists in Madrid, Spain. Complete Peer review History: http://www.sciencedomain.org/review-history/19846 Received 23 rd May 2017 Accepted 15 th June 2017 Published 4 th July 2017 ABSTRACT Objectives: Equigan is an anabolic androgenic steroid that developed for veterinary use to improve the food producing animal growth rate through promoting protein synthesis and muscle growth. The current study aimed to investigate the possible prophylactic effect of star anise extracts (SAE) response of to Equigan induced testicular injury, oxidative stress, P53 expression in male rats. Materials and Methods: Forty adult male rats were equally divided into four groups. 1 st Control Original Research Article