Turkiye Klinikleri J Gynecol Obst 2016;26(2) 114 ucinous microglandular adenocarcinoma (MGA) is an uncommon subtype of endometrial adenocarcinoma which can be confused with mucinous adenocarcinoma (MUC-AD) and microglandular hyperplasia of the cervix or mucinous proliferations of the endometrium. 1-3 This neoplasm can mimic microglandular hyperplasia (MGH) particularly, which is characterized by closely packed glands lined by cuboidal or colum- Microglandular Adenocarcinoma of the Endometrium: Case Report ABSTRACT We report a case of endometrial microglandular adenocarcinoma which can be con- fused with microglandular hyperplasia and mucinous adenocarcinoma of the cervix and mucinous proliferation of the endometrium. A 54-year-old postmenopausal woman presented with vaginal bleeding. Histologically, endometrial biopsy was characterized by closely packed microglandular and mucinous glandular areas, which is lined by cuboidal and columnar cells. There was a multi- tude of neutrophils in microglandular lumens and stroma. Immunohistochemically, focal positiv- ity for vimentin, CEA, estrogen and progesterone receptors were seen. The histology was suspicious for malignancy that might be compatible with microglandular adenocarcinoma of the endometrium resembling microglandular hyperplasia of the cervix. In the final workout of the hysterectomy specimen, we determined a superficial microglandular adenocarcinoma with no myometrial inva- sion. Several tubal, eosinophilic syncytial and squamous metaplasia areas were present. Patholo- gists require sufficient clinical information, morphologic experience and immunohistochemical assistance to make the correct pathological diagnosis in such confounding neoplasms. Key Words: Endometrial neoplasms; adenocarcinoma; hyperplasia; metaplasia ÖZET Endometriumun müsinöz proliferasyonu, serviksin müsinöz adenokarsinomu ve mikrog- landüler proliferasyonu ile karışabilen bir endometrial mikroglandüler adenokarsinom vakası sun- duk. 54 yaşında postmenopozal kadın hasta vajinal kanama ile başvurdu. Histolojik olarak endometrial küretaj, küboidal ve kolumnar hücrelerle döşeli, sıkı paketlenmiş mikroglandüler ve müsinöz glandüler alanlarla karakterizeydi. Mikroglandüler lümenlerde ve stromada çok sayıda nötrofil mevcuttu. İmmünohistokimyasal olarak, Vimentin, CEA, Östrojen ve Progesteron resep- törleri ile fokal pozitivite izlendi. Histolojisi serviksin mikroglandüler hiperplazisine benzeyen en- dometrial mikroglandüler adenokarsinoma benzerliği yönüyle malignensi açısından şüpheliydi. Ardından gelen histerektomi spesmeninde, miyometrial invazyon göstermeyen yüzeyel bir mik- roglandüler adenokarsinom belirlendi. Çok sayıda tubal, eozinofilik sinsityal ve skuamöz metaplazi alanları izlendi. Böyle şüpheli neoplazmların doğru patolojik tanısı için patologların klinik bilgi, morfolojik inceleme ve immünohistokimyasal destek konusunda dikkatli olmaları gerekmektedir. Anahtar Kelimeler: Endometriyal tümörler; adenokarsinom; hiperplazi; metaplazi Turkiye Klinikleri J Gynecol Obst 2016;26(2):114-8 Perihan Özlem DOĞAN, a Hamide SAYAR, a Gürkan KIRAN, b Abdullah AYDIN, c Emel CANAZ b Departments of a Pathology, b Gynecology and Obstetrics, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş c Department of Pathology, İstanbul Medeniyet University Faculty of Medicine, İstanbul Geliş Tarihi/Received: 20.01.2014 Kabul Tarihi/Accepted: 25.04.2014 An abstract presentation of this case was accepted to 18th International Meeting of the European Society of Gynaecological Oncology (ESGO) 2013. Yazışma Adresi/Correspondence: Perihan Özlem DOĞAN Kahramanmaraş Sütçü İmam University Faculty of Medicine, Department of Pathology, Kahramanmaraş, TÜRKİYE/TURKEY tadby@hotmail.com doi: 10.5336/gynobstet.2014-38682 Copyright © 2016 by Türkiye Klinikleri OLGU SUNUMU