Research Article The Association between Adiponectin Single Nucleotide PolymorphismsandSideEffectsofIsotretinoininAcnePatients MunirGarba, 1 OmarF.Khabour , 1 KaremH.Alzoubi , 2 Ahmed Abu-Siniyeh, 3 andFirasAl-Qarqaz 4 1 Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan 2 Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan 3 Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia 4 Department of Dermatology, Faculty of Medicine, Jordan University of Science, Technology, Irbid, Jordan Correspondence should be addressed to Omar F. Khabour; khabour@just.edu.jo Received 13 January 2020; Revised 27 March 2020; Accepted 16 April 2020; Published 29 April 2020 Academic Editor: E. Helen Kemp Copyright © 2020 Munir Garba et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Acne is a common condition of pilosebaceous follicle especially among young. Clinically, the most used medication in the treatment of moderate to severe acne is oral isotretinoin. However, interindividual variability in therapeutic response to isotretinoin and many side eﬀects such as musculoskeletal pain, headache, and alteration in lipid proﬁle can be seen with this treatment. Aim. In this study, the eﬀect of genetic polymorphisms, rs2241766 and rs1501299, of the adiponectin gene was investigated in relation to the side eﬀects of isotretinoin-treated young adult acne patients (n � 230). Methods. Several biochemical parameters were measured at baseline and after treatments with isotretinoin. e ADIPOQ gene SNPs, rs2241766 and rs1501299, were genotyped in 230 patients. Results. Alterations in lipid proﬁle with a signiﬁcant increase of ALT (P � 0.007) were detected after isotretinoin treatment. Moreover, percentage change in HDL following isotretinoin treatment was signiﬁcantly associated with rs1501299 (P � 0.008). On the other hand, no associations between examined SNPs and side eﬀects of isotretinoin and other lipid parameters (total cholesterol, LDL, and triglycerides) or liver function enzymes (ALT and AST) were detected. Conclusions. Current ﬁndings showed that rs1501299 of the ADIPOQ gene might be associated with changes in HDL level in acne patients following treatment with isotretinoin. 1.Introduction Acne is a common skin condition of the pilosebaceous follicle, identiﬁed by a variety of noninﬂamed (comedons) and inﬂammatory lesions [1, 2], which primarily aﬀects the face, upper trunk, upper arms, and back [3]. e prevalence and the severity of acne is highest among the adolescence, aﬀecting up to 91% of males and 79 % of females of this group [4] and often persist well in adulthood [5]. e treatment of acne is based on the severity and the appearance of acne lesions [6]. Oral isotretinoin (13-cis- retinoic acid) is considered to be the most eﬀective medi- cation in the treatment of moderate-to-severe form of acne vulgaris [7]. However, the use of isotretinoin is associated with serious side eﬀects [8], including depression and sui- cidal behavior [9, 10], elevated liver enzymes, teratogenicity, arthralgia, headache, and myalgia [11], and acute kidney injury [12, 13]. Adiponectin, a 30 KDa product of the ADIPOQ gene [14], is an abundant protein in human adipose tissues [15]. In addition, the circulating level of adiponectin in blood ranges between 2 and 30 mg/L in human [16] and about 1.5 times higher in females than males [17]. Adiponectin plays an important role in body metabolism and immune response [18, 19]. Changes in adipocytokine levels have been reported to be associated with isotretinoin medication [20–24]. For Hindawi Dermatology Research and Practice Volume 2020, Article ID 3176521, 7 pages https://doi.org/10.1155/2020/3176521