Int. J. Hyg. Environ. Health 207 (2004); 31 ± 44 http: // www.elsevier-deutschland.de/artikel/647581 International Journal of Hygiene and Environmental Health Interdisciplinary diagnostics in environmental medicine ± findings and follow-up in patients with chronic medically unexplained health complaints Caroline E. W. Herr a , Ines Kopka a , Jens Mach a , Bettina Runkel a , Wolf-Bernhard Schill b , Uwe Gieler c , Thomas F. Eikmann a a Outpatient Department for Environmental Medicine, Institute of Hygiene and Environmental Medicine, University of Giessen, Giessen, Germany b Center of Dermatology and Andrology, University of Giessen, Giessen, Germany c Clinic for Psychosomatic Medicine and Psychotherapy, University of Giessen, Giessen, Germany Received October 9, 2002¥Revision received July 21, 2003¥Accepted August 9, 2003 Abstract Problem: In patients attributing their chronic, medically unexplained complaints to environmental factors the greatest challenge is to overcome their disabling belief in toxicogenic explanations. Method: Patients presenting with health complaints that they attributed to environmental causes in an environmental outpatient department (EOPD) within a university medical center in Germany were studied. An interdisciplinary review of previously diagnosed medical conditions, current clinical consultations, personal risk communication and therapeutic advice is presented. Additionally, patient contentedness, complaint development, and belief in environmental attribution in a follow-up interview are given. Results: The open, prospective study comprises 51 patients reporting more than one complaint. Symptoms had lasted for more than 3 years in 63% of the cases. Seventy percent attributed their complaints to more than one environmental cause. The clinical diagnostic procedure reduced the number of prediagnosed clinical conditions by 50%. Numerous foregoing environmental laboratory analyses had overestimated toxicologically relevant findings. These were not confirmed in 80% (8/10) of the cases. In 8% (n  4) of the patients a relevant environmental or occupational medical condition was found. A mental or behavioral condition was not considered to have first priority in explaining all complaints in 43% (22/51) of the patients. Among these, mostly respiratory or skin-related diseases were found. All patients contacted participated in a follow-up study after a minimum of 21 months. Sixty-seven percent reported having felt that they were taken seriously, 38% felt better after the beginning of the study, and 45% were no longer certain about the importance of the environmental attribution. Since 83% of the patients with a preceding residential diagnosis of MCS or SBS still believed in environmental causes of their complaints in the follow-up study, we conclude that these prediagnoses appear to be a risk for persisting attribution of the environmental factor. About one third (37%) of these patients with complaints that had not been medically explained by an organic condition during interdisciplinary diagnostics had meanwhile consulted a psychotherapist. 1438-4639/04/207/01-031 $30.00/0 Corresponding author: Dr. Caroline Herr, Institute of Hygiene and Environmental Medicine, Justus-Liebig-University of Giessen, Friedrichstrasse 16, D-35385 Giessen, Germany. Phone:  496419941450, Fax:  496419941459, E-mail: caroline.herr@hygiene.med.uni-giessen.de