IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 16, Issue 1 Ver. II (January. 2017), PP 70-74 www.iosrjournals.org DOI: 10.9790/0853-1601027074 www.iosrjournals.org 70 | Page Study of ‘C ‘Cells of Thyroid Gland, its Presence & Position in Fetuses of Different Gestational Age Dr. Nityanand Srivastava 1 ,Dr. Jayant Kumar Verma 2 ,Nand Kishor Gupta 3 ,Dr. Adil Asghar 4 ,Dr. Monika Srivastava 3 Professor 1 , Associate Professor 2 , Lecturer 3 , Assistant Professor 4 Department Of Anatomy, Up University Of Medical Sciences, Saifai, Etawah Up. Abstract: Thyroid gland has follicular structure and in follicle the cells are cuboidal in nature. The colloids are filled in follicles. The presence of ‘c’ cells and its location in thyroid is a considerable difference of opinion among researchers. My present study is done for enhancement of academic knowledge and support of different opinion given in regards to presence and position of ‘c’ cells in thyroid gland. Keywords: Thyroid gland, ‘C’ cells, Follicular, Epifollicular I. Introduction thyroid gland is a brownish red highly vascular organs situated anteriorly in lower part of neck at the level of 5 th to 7 th cervical vertebra and 1 st thoracic vertebra. Davis (1923) demonstrated that thyroid gland is 1 st identifiable in embryo of about 20 somite as a median thickening of endoderm in the floor of pharynx between the 1 st and 2 nd pharyngeal pouch and immediately dorsal to aortic sac .The thyroid gland ensheathed by a pretracheal layer of deep cervical fascia. Its wt is somewhat 25 gms. The thyroid parenchyma is mainly derived from the endoderm of thyroglossal duct. It is usually considered to develop in to separate follicle approximately spherical structure .02 to .09 mm in diameter, a centre core of colloid surrounded by a single layer of epithelial cells and enclosed in a basal lamina. II. Material And Method Thyroid gland of 20 fetuses was dissected. After macroscopic studies of thyroid gland, the tissue is taken for microscopic studies. The fetuses were collected at different time interval from department of Gynecology of UPUMS Saifai. A jar of about 10 liter capacity containing 5 liter 10% formalin solution was kept in labor room for collection of fetuses resulting from intrauterine death and as product of MTP. The fetuses were transferred immediately to Department of Anatomy UPUMS. Each fetus was dissected to expose thyroid gland. After dissection the thyroid was studied for morphological structure and after that two separate tissues was taken for each Rt and Lt lobe. The size of tissue taken was roughly 5 mm * 5 mm. The tissue was allowed to macroscopic examination and histological processing to prepare the tissue for microscopic studies. The histological process involved were fixation, dehydration, clearing, and wax impregnation, section cutting and staining. The section so stained was mounted with DPX under cover slip and the slide so prepared was examined under light microscope to study. The microphotograph of suitable slide was taken. For the study of microscopic tissue, we categorized the fetuses in different groups according to their age. Group Age GroUP 1 5 – 15 weeks 2 16 – 25 weeks 3 26 – 35 weeks 4 36 – 42 weeks III. Observation The Observation Of Microscopic Study Is Shown In Table. The Four Criteria Are Studied As Follows: 1. Presence and absence of colloids 2. Presence f „c „ cells 3. Position of „c „ cells in follicles 4. Presence and absence of follicular structure Our observation shows that the colloids are present in all the tissue slides. The „C‟ cells are present only 18 fetuses. The serial number and age groups are 4 (16-25 weeks), 8 (26-35 weeks), 10 (36-42 weeks)