480 Bangladesh Journal of Medical Science Vol. 19 No. 03 July’20 Original article: Possible role of grape fruit in controlling hyperglycemia and associated complications: Better glycemic control in healthy subjects through fruits fbers as compared to fruit juices Somia Gul *1 , Humera Khatoon 2 , Nameera Ahmed 3 , Haneen Rashid 4 , Agha Zeeshan Mirza 5 Abstract: Background: Diabetes is regarded as a chronic disorder, which is globally spreading at an alarming rate and individuals are being pushed down by the burden of diabetes. Diferent measures and control programs have been conducted for awareness of this disaster endocrine disease as its associated complications. Objective: Current study has been conducted to evaluate the hypothesis that whole fruits provide better glycemic control than fruit juices. Materials & Methods: The study includes two groups of healthy volunteers, one group was on whole fruits while another group was supplied with fruit juices of same fruits and fasting blood sugar and random blood sugar were monitored. Results: Results revealed that whole grapefruit and orange fruit play efective role in maintaining random blood sugar levels in comparison to juices. Further suggested that dietary fbers are not only efective in regulating blood sugar, but also infuence on blood pressure and pulse rate. Conclusion: Based on above fndings, it has been concluded that type 2 diabetes patients can achieve better glycemic control by dietary fbers rather than juices, and it may be helpful in controlling diabetes related complication such as high blood pressure. Keyword: Type 2 diabetes mellitus (T2DM); fruit fbers; fruit juice; healthy life style. Correspondence to: Dr. Somia Gul, Associate Professor/ Ex-Chairperson, Faculty of Pharmacy, Jinnah Uni- versity for Women, Karachi. drsomi1983@yahoo.com, SomiaGul@juw.edu.pk 1. Somia Gul, Faculty of Pharmacy,Jinnah Uni. for Women, Karachi, Pakistan. 2. Humera Khatoon, Faculty of Pharmacy,Jinnah Uni. for Women, Karachi, Pakistan. 3. Nameera Ahmed, Faculty of Pharmacy,Jinnah Uni. for Women, Karachi, Pakistan. 4. Haneen Rashid, Faculty of Pharmacy,Jinnah Uni. for Women, Karachi, Pakistan. Agha Zeeshan Mirza, Science and Technology Unit, Umm Al-Qura University, Mecca, Saudi Arabia Bangladesh Journal of Medical Science Vol. 19 No. 03 July’20. Page : 480-485 DOI: https://doi.org/10.3329/bjms.v19i3.45866 Introduction Type 2 diabetes mellitus (T2DM), non-insulin dependent diabetes mellitus, is the most rapidly growing disease, estimated to afect 439 million adults by 2030. The rate is faster in developing countries than developed countries 1 which in turn results in higher healthcare expenditure 2 . Thus it becomes a priority to identify diferent measures and control programs should be arranged to prevent the disease. Dietary factors contribute to T2DM and promote early diabetes in healthy individuals and increased mortality and morbidity in type 2 diabetic patients. Delayed development and prevention of T2DM was shown to be efective by lifestyle intervention which involved dietary modifcation 3, 4 . The WHO has recommended the public for consuming more fruit and vegetables per day to minimize the risk of dietary factors and reduce the incidence of T2DM 5 . In previous studies, it is found that increased daily intake of fruits than juices could signifcantly reduce the risk of developing T2DM 6, 7, 8 . Recent studies show a relationship between the intake of fruit and vegetables and the risk of T2DM 9, 10, 11 . Many plant based drugs are also in use along with the synthetic drugs for treatment of T2DM 12 . In addition, a study showed the dose–response relations and indicate that relatively high fruit intake may still decrease the risk of T2DM 13 . Fruits and vegetables have many benefcial nutrients and phytochemicals that are thought to protect against hypertension, obesity and other diseases 14, 15, 16 and diabetes 17- 20, 8 . However, epidemiologic data on fruits and vegetables intake and its relationship with type 2 diabetes are very limited 21 .