_____________________________________________________________________________________________________ *Corresponding author: E-mail: felix.nwafor@unn.edu.ng; Journal of Pharmaceutical Research International 32(21): 70-78, 2020; Article no.JPRI.56218 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Antioxidant and Hepatoprotective Potentials of Lasimorpha senegalensis Schott Leaf Extract on Carbon Tetrachloride-induced Liver Damage in Rats Chinyere Blessing Chigor 1 , Felix Ifeanyi Nwafor 2* , Edith Ugwuja 1 and Chisimdi S. Obi 1 1 Department of Plant Science and Biotechnology, University of Nigeria, 41001 Nsukka, Nigeria. 2 Department of Pharmacognosy and Environmental Medicine, University of Nigeria, 41001 Nsukka, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Authors CBC and FIN designed the study, performed the statistical analysis, wrote the protocol and wrote the first draft of the manuscript. Authors EU and CSO managed the analyses of the study and the literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2020/v32i2130754 Editor(s): (1) Dr. Mohamed Fathy, Assiut University, Egypt. Reviewers: (1) Iwona Rybakowska, Medical University of Gdansk, Poland. (2) Christopher Larbie, KNUST, Ghana. Complete Peer review History: http://www.sdiarticle4.com/review-history/56218 Received 10 February 2020 Accepted 14 April 2020 Published 03 September 2020 ABSTRACT Aims: The present study assessed the antioxidant and hepatoprotective potentials of the methanolic leaf extract of Lasimorpha senegalensis – a medicinal plant used by the indigenous people of Nigeria to treat hepatitis and feverish conditions. Place and Duration of Study: The research work was conducted in the Department of Pharmacognosy and Environmental Medicine and Department of Plant Science and Biotechnology, both in the University of Nigeria, Nsukka, from May to August, 2019. Methodology: Phytochemical analyses and acute toxicity study of the sample followed standard procedures. In vitro antioxidant assay was by DPPH and H 2 O 2 models. A total of 25 male Wistar albino rats (120 – 150 g) were grouped into five, each group with five animals. Hepatotoxicity was induced with carbontetrachloride (1 ml/kg). The treatment groups (3-5) received extract (200 and 400 mg/kg) and Silymarin (100 mg/kg). Endogenous antioxidants (superoxide dismutase, catalase, glutathione peroxidase), plasma malondialdehyde and liver enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphate) were determined after treatment. Original Research Article