Research Article FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents Gabrielle Araujo do Nascimento , 1 Neiva Leite, 2 Lupe Furtado-Alle, 1 MayzaDalcinTeixeira, 1 RicardoLehtonenRodriguesdeSouza, 1 GerusaEisfeldMilano , 2 Larissa Rosa da Silva, 2 Juliana Pizzi, 2 Wendell Arthur Lopes , 3 MariadeF´ atima Aguiar Lopes, 2 AnaCl´ audia Kapp Titski, 2 and Luciane Viater Tureck 1,4 1 Department of Genetics, Centro Polit´ ecnico, Setor de Ciˆencias Biol´ ogicas, Federal University of Paran´ a, Francisco H. dos Santos, 210 Jardim das Am´ ericas, 81531-970 Curitiba, PR, Brazil 2 Department of Physical Education, Federal University of Paran´ a, Coração de Maria, 92 Jardim Botˆ anico, 80215-370 Curitiba, PR, Brazil 3 Department of Physical Education, State University of Maringa, Av. Colombo 5790, 87020-900 Maringa, PR, Brazil 4 Academic Department of Education, Federal University of Technology–Paran´ a, Av. Monteiro Lobato Km 04, 84016-210 Ponta Grossa, PR, Brazil Correspondence should be addressed to Luciane Viater Tureck; luviater@gmail.com Received 30 November 2017; Revised 23 March 2018; Accepted 8 April 2018; Published 26 April 2018 Academic Editor: Moonseong Heo Copyright © 2018 Gabrielle Araujo do Nascimento et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. e rs9939609 SNP (T > A) in FTO gene is associated with obesity and type 2 diabetes. e present study aimed at verifying whether this SNP influenced biochemical outcomes of children and adolescents who are overweight/obese submitted to a program of physical exercise and also if there was influence on basal levels of these biochemical variables. Methods. e sample was composed by 432 children and adolescents grouped in three ways (obese, overweight, and normal weight); of these, 135 children and adoloescents who are obese and overweight were submitted to a physical exercise program for 12 weeks. All were genotyped by TaqMan SNP genotyping assay. Results. e children and adolescents who are overweight/obese and carriers of AA genotype had higher levels of insulin (p � 0.03) and HOMA (p � 0.007) and lower levels of glucose (p � 0.003), but the SNP did not modulate the response to physical exercise. Conclusions. In our study, the rs9939609 AA genotype was associated with parameters related to insulin metabolism but did not interact with physical exercise. 1. Introduction Obesity is a multifactorial disease influenced by several genetic factors, including the fat mass and obesity-associated (FTO) gene [1, 2], which is expressed in the whole organism, mainly in hypothalamus, and thus associated with energy balance regulation [3]. FTO gene product is a 2-oxoglutarate dependent nucleic acid demethylase [4] which can have several target genes, including genes related to metabolism. One of its most studied SNPs is the rs9939609 SNP (T > A), associated with obesity, type 2 diabetes, and other metabolic complications [1, 5, 6]. e body weight increase associated with rs9939609 A-allele could be related to an increase in FTO expression, since FTO transcripts are more abundant in risk allele carriers [7]. Many studies have shown association between A-allele and increased food intake and reduced satiety [8–11]; however, the interaction of the rs9939609 SNP with energy expenditure has not yet been clarified, since some studies found interaction and others did not [12]. Besides the effect induced by rs9939609 A-allele in several basal metabolic parameters [13–16], it can also interfere in the Hindawi Journal of Obesity Volume 2018, Article ID 3134026, 8 pages https://doi.org/10.1155/2018/3134026