Jemds.com Original Research Article J. Evolution Med. Dent. Sci./eISSN- 2278-4802, pISSN- 2278-4748/ Vol. 7/ Issue 33/ Aug. 13, 2018 Page 3653 PROFILE OF HAEMOPHILIA PATIENTS IN MANIPUR Irom Anil Singh 1 , T. Ginzaniang 2 , P. Vedanti Devi 3 , A. Meina Singh 4 , N. Dhanachand Singh 5 , Kh. Yoihenba 6 , Sadam Hussain 7 , Kh. Peepa 8 1 Assistant Professor, Department of Medicine, JNIMS, Imphal, Manipur, India. 2 Associate Professor, Department of Medicine, JNIMS, Imphal, Manipur, India. 3 Assistant Professor, Department of Medicine, JNIMS, Imphal, Manipur, India. 4 Professor, Department of Transfusion Medicine, RIMS, Imphal, Manipur, India. 5 Senior Resident, Department of Medicine, JNIMS, Imphal, Manipur, India. 6 Senior Resident, Department of Medicine, JNIMS, Imphal, Manipur, India. 7 Postgraduate Trainee, Department of Medicine, JNIMS, Imphal, Manipur, India. 8 Postgraduate Trainee, Department of Medicine, JNIMS, Imphal, Manipur, India. ABSTRACT BACKGROUND The deficiency of blood coagulation factor VIII (F-VIII) and factor IX (F-IX) are called Haemophilia A and B respectively. They are inherited as X-linked recessive traits. They are the most common hereditary haemorrhagic disorders. Patients have increased bleeding tendency especially the joints, muscles and after any trauma. The treatment for haemophilia is by providing factors VIII and IX. MATERIALS AND METHODS The aim of the study was to know various clinical manifestations of the disease in Manipur. The study was conducted in the Department of Medicine, Jawaharlal Nehru Institute of Medical Sciences, Imphal from 1 st August 2017 till 31 st May 2018. The study design was a descriptive study. Any patient who is diagnosed as haemophilia A or B was included in the study. Patients who had any other bleeding disorder, refused to give consent for the inclusion in the study and patients belonging to other states of India were excluded from the study. RESULTS Sixty-five patients presented with complaints of increased bleeding. Thirty-five patients were included in the analysis. Out of these 35 patients, there were 30 (85.7%) cases of Haemophilia A and 5 (14.53%) cases of Haemophilia B. There was no family history in 25 cases (71.43%). The patients in the study had presented pain and swelling in the joints in majority consisting of 19 cases (54.29). Not a single patient was in prophylaxis due to lack of adequate factors. CONCLUSION Early treatment after any bleeding episodes and prophylaxis will be essential in preventing various complications. KEY WORDS Haemophilia A, Haemophilia B, Anti-Haemophilic Factors. HOW TO CITE THIS ARTICLE: Singh IA, Ginzaniang T, Devi PV, et al. Profile of haemophilia patients in Manipur. J. Evolution Med. Dent. Sci. 2018;7(33):3653-3656, DOI: 10.14260/jemds/2018/820 BACKGROUND There are many inherited bleeding disorders due to deficiency of coagulation factors. Among them, the deficiency of blood coagulation factor VIII (F-VIII) and factor IX (F-IX) are called Haemophilia A and B respectively. They are inherited as X-linked recessive traits. They are the most common hereditary haemorrhagic disorder. They along with Von Willebrand’s disease constitute 95% to 97% of all the inherited deficiencies of coagulation factors. Molecular analysis, carrier detection and prenatal diagnosis is an important step in the prevention of haemophilia in developing countries. (1),(2) In the past, this illness was often neglected. However, in the last three decades, safe and effective treatment is ‘Financial or Other Competing Interest’: None. Submission 30-06-2018, Peer Review 31-07-2018, Acceptance 06-08-2018, Published 13-08-2018. Corresponding Author: T. Ginzaniang, Department of Medicine, JNIMS, Porompat, Imphal East-795005, Manipur, India. E-mail: gindr.7@gmail.com DOI: 10.14260/jemds/2018/820 developed for the illness. Gene therapy has been able to cure patients suffering from haemophilia in the third millennium. Four-fifths of the world’s haemophiliacs are in India, however, due to poor socio-economic conditions majority of patients still receive no treatment at all. (2) Among the haemophiliacs, the haemophilia A is more common and represents 80-85% of total haemophilia. It is about 7 times more than haemophilia B. This illness is seen in about 1 in 25,000 male births in developed countries like the US whereas in India it is 1 in 30,000 - 60,000 male births. However, all races and economic groups are affected equally. (3) Based on the WFH’s (World Federation of Haemophiliac) annual global surveys, currently there are approximately 400,000 patients suffering from the disease. (4),(5) The approach to the diagnosis of haemophilia is done from the history of bleeding, clinical findings, family history and demonstration of factor deficiency. The disease has a history of easy bruising in the early childhood, spontaneous bleeding into the joint, muscles and soft tissue without any apparent causes and excessive bleeding after trauma or surgery. Family history is usually available in about two- thirds of all the patients. The diagnosis of the illness is