118 Malays J Med Sci. Nov–Dec 2016; 23(6): 118–122 www.mjms.usm.my © Penerbit Universiti Sains Malaysia, 2016 For permission, please email:mjms.usm@gmail.com Introduction The adrenal gland is a frequent site of neoplastic diseases, including both primary as well as metastatic diseases. Primary adrenal lymphoma (PAL) is a rare condition with only less than 150 such cases reported worldwide (1). Adrenal masses are found in the functional and non-functional adrenal adenomas, pheochromocytomas, infection sites, traumatic hemorrhage, adrenocortical carcinomas, and metastatic organs (2). Here, we report a case of bilateral adrenal difuse large B-cell lymphomas in association with hypercalcemia. Case Report In June 2012, a 65-year-old male presented with pain in the left hip, anorexia, weight loss, and night sweats for six months. The history of the patient was insignifcant. General physical examination revealed 106/80 mm Hg blood pressure without any postural drop. No lymphadenopathy was observed, and abdominal examination revealed mild splenomegaly. Initial investigations revealed hemoglobin of 11.2 g/dl, mean corpuscular volume of 73.2 fL, mean corpuscular hemoglobin of 29 pg, total leukocyte count of 10.4, and platelet count of 2.13×106. The patient showed normal liver function test. The kidney function tests revealed To cite this article: Mir SA, Masoodi SR, Wani AI, Syed NA, Hameed I. Calcitriol-mediated reversible hypercalcemia in a patient with primary adrenal lymphoma. Malays J Med Sci. 2016;23(6):118–122. http://dx.doi.org/10.21315/ mjms2016.23.6.13 To link to this article: http://dx.doi.org/10.21315/mjms2016.23.6.13 Abstract Primary adrenal lymphomas (PAL) are rare occurrences with only less than 150 cases reported in the literature. Two-thirds of these cases were reported in the last decade due to the advancements in imaging techniques and immunohistochemistry. The non-specifc signs and symptoms have resulted in a delayed onset of symptoms and diagnosis of these tumors. Reports of the results of chemotherapy are not gratifying, and most patients die within one year of the diagnosis. We report a 65-year-old male with adrenal non-Hodgkin’s lymphoma (NHL), who presented with hypercalcemia and renal failure. We reviewed all adrenal NHL cases presented with hypercalcemia and attempted to comprehend its etiology and overall survival efect. Keywords: hypercalcemia, adrenal insufciency, lymphoma, calcitriol Calcitriol-mediated Reversible Hypercalcemia in a Patient with Primary Adrenal Lymphoma Shahnaz Ahmad MIR 1 , Shariq Rashid MASOODI 1 , Arshad Iqbal WANI 1 , SYED Nisar Ahmad 2 , Iqra HAMEED 3 1 Department of Endocrinology, Sheri-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, 190011, India 2 Department of Oncology, Sheri-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, 190011, India 3 Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, 190006, India Submitted: 8 Feb 2015 Accepted: 22 July 2015 Online: 7 Dec 2016 Case Report