Research Article Patil et al., 10(9-10): Sep/Oct, 2019:6359-6363]
CODEN (USA): IJPLCP ISSN: 0976-7126
© Sakun Publishing House (SPH): IJPLS
6359
INTERNATIONALJOURNALOFPHARMACY&LIFESCIENCES
(Int. J. of Pharm. Life Sci.)
Validation for Moxifloxacin Tablet
Pankaj Patil*, Deepak Kumar Gupta, Raju Choukse and Rakesh Patel
School of Pharmacy, Dr. APJ Abdul Kalam University, Indore (M.P.) - India
Abstract
Quality Assurance includes management of the quality of raw materials, assemblies, products and component,
management, production, validation and inspection processes. Validation is action of providing in accordance with
principle of GMP, that any procedure, process, equipment, materials activity or system actual leads to expected
results". At various stages in a validation/qualification exercise there is need for protocols, documentation,
procedure, equipment, specifications and acceptance criteria for test results. The FDA has the authority and
responsibility to inspect and evaluate process validation performed by manufactures. The cGMP for validated
formulations (drugs) manufacturing required that drug product be produced with a high degree of assurance meeting
all the attributes they are intended to process of meeting all the attributes they are intended to process. All the
physical parameters of all three batches were found well within the acceptable limits.
Key-words: Quality Assurance, Validation, Good Manufacturing Practices & FDA.
Introduction
"Quality Assurance is defined as the maintenance of
a desired level of quality in a service or product,
especially by means of attention to every stage of the
process of delivery or production. It is the systematic
measurement, comparison, with a standard,
monitoring of processes and associated feedback loop
that confers error prevention.
QA includes principles like, "fit for purpose" and
"right first time". Quality Assurance therefore
incorporates GMP and other factors". QA includes
management of the quality of raw materials,
assemblies, products and component, management,
production and inspection processes. (Potdar 2006).
Process validation (P.V.) may be defined as "a
documented programmed which provide a high
degree of assurance that a specific process will
consistently produce a product meeting its pre-
determined specifications and quality attributes."
Various regulatory bodies have been various
definitions to validation.
* Corresponding Author
E.mail: cemoon06@gmail.com
Some consideration should be exercised when
selecting the process validation strategy. Amongst
these should be the use of different lots of active raw
material and major excipients, batch produced on
different shifts, the use of different equipment and
facilities dedicated for commercial production,
operating range of the critical processes, and a
thorough analysis of the process data in case of re-
qualification and re-validation, During the processing
of the validation batches, extensive sampling and
testing should be performed on the product at various
stage and should be documented comprehensively.
Fig. 1: General Type of Process Validation