Research Article Serum Albumin Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis Wandong Hong, 1 Suhan Lin, 1 Maddalena Zippi, 2 Wujun Geng, 3 Simon Stock, 4 Zarrin Basharat, 5 Bicheng Cheng, 6 Jingye Pan, 7 and Mengtao Zhou 8 1 Department of Gastroenterology and Hepatology, Te First Afliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 2 Unit of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, Rome, Italy 3 Department of Anesthesiology, Te First Afliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 4 Department of Surgery, World Mate Emergency Hospital, Battambang, Cambodia 5 Microbiology & Biotechnology Research Lab, Department of Environmental Sciences, Fatima Jinnah Women University, Rawalpindi 46000, Pakistan 6 Zhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, Te First Afliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China 7 Intensive Care Unit, Te First Afliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 8 Department of Surgery, Te First Afliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China Correspondence should be addressed to Mengtao Zhou; studyzhoumengtao@sina.com Received 26 May 2017; Revised 4 September 2017; Accepted 11 September 2017; Published 24 September 2017 Academic Editor: Yousuke Nakai Copyright © 2017 Wandong Hong et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background and Aims. To investigate the association between serum albumin levels within 24hrs of patient admission and the development of persistent organ failure in acute pancreatitis. Methods. A total of 700 patients with acute pancreatitis were enrolled. Multivariate logistic regression and subgroup analysis determined whether decreased albumin was independently associated with persistent organ failure and mortality. Te diagnostic performance of serum albumin was evaluated by the area under Receiver Operating Characteristic (ROC) curves. Results. As levels of serum albumin decrease, the risk of persistent organ failure signifcantly increases ( trend < 0.001). Te incidence of organ failure was 3.5%, 10.6%, and 41.6% in patients with normal albumin and mild and severe hypoalbuminaemia, respectively. Decreased albumin levels were also proportionally associated with prolonged hospital stay ( trend < 0.001) and the risk of death ( trend < 0.001). Multivariate analysis suggested that biliary etiology, chronic concomitant diseases, hematocrit, blood urea nitrogen, and the serum albumin level were independently associated with persistent organ failure. Blood urea nitrogen and the serum albumin level were also independently associated with mortality. Te area under ROC curves of albumin for predicting organ failure and mortality were 0.78 and 0.87, respectively. Conclusion. A low serum albumin is independently associated with an increased risk of developing of persistent organ failure and death in acute pancreatitis. It may also be useful for the prediction of the severity of acute pancreatitis. 1. Introduction Tough most patients with acute pancreatitis (AP) have a benign clinical course, approximately 10%–20% of patients develop persistent organ failure (defned as organ failure lasting for ≥48 hours) associated with signifcant mortality of at least 30% [1, 2]. Recent international consensus identifed that persistent organ failure is the key determinant of severity regardless of the presence or absence of local pancreatic com- plications [3]. Early identifcation of patients likely to develop persistent organ failure would help physicians to select those patients who would beneft the most from close surveillance or aggressive intervention [4]. Existing scoring system such as the Bedside index of severity in acute pancreatitis (BISAP) [5] and the Harmless acute pancreatitis score (HAPS) [6] have moderate diagnostic accuracy in the prediction of persistent Hindawi Canadian Journal of Gastroenterology and Hepatology Volume 2017, Article ID 5297143, 10 pages https://doi.org/10.1155/2017/5297143