Journal of Veterinary & Marine Sciences JVMS, 1(1): 15-17 www.scitcentral.com Short Communication: Open Access SciTech Central Inc. J Vet Marine Sci (JVMS) 15 Chemotherapy of Genital Warts Arsalan Khan * * Livestock Research and Development Station, Paharpur, Dera Ismail Khan-29050, Pakistan. Received August 12, 2019; Accepted August 28, 2019; Published October 09, 2019 ABSTRACT Genital warts are the most commonly sexually transmitted viral infection of humans caused by Human Papillomavirus, affecting both male and female sexes, clinically characterized by the appearance of external warts on the genital organs including penis, scrotum, vulva, anus and perineal area. The present study was designed for the investigation of chemotherapeutic agents for the successful treatment of genital warts in terms of recovery of patients and clearance percentage of genital organs from the warts. For this purpose, a total of 12 patients infected with genital warts were selected and randomly distributed into four different groups, each group comprising 03 patients. Group A was treated using locally available wart removal preparation Dewart ® (Verrugon, Milk Acid), Group B was treated using Podophyllotoxin 15-25%, acquired from chemical suppliers, Group C was treated using locally available Duofilm™ (Salicylic Acid 16.7% w/v, Lactic Acid 16.6% w/v) and Group D served as negative control. The results of the current study revealed that the standard and most effective treatment of the genital warts is found to be Podophyllotoxin 15-25%, which showed 100% recovery of the patients and 100% clearance of their genital areas from the stubborn warts. However, Duofilm™ was also found effective, because all the patients were recovered and 80% warts were cleared off from their genitalia. But the warts did not go off with the local brands of Dewart ® nor spontaneously recovered. Keywords: Genital warts, Dewart ® , Podophyllotoxin, Duofilm™, Clearance percentage INTRODUCTION Genital warts, scientifically known as Condylomata acuminata, are the sequel of venereal diseases infecting large populations, even endemic in some zones of the world. The etiological agent of the disease, Human Papillomavirus (HPV), is known to be the direct cause of genital warts in both males and females. In males it only infects epithelium of genitalia and is characterized by visible warts, while, in females it is more hazardous causing genital warts as well as cervical cancer [1,2]. Human Papillomavirus is potentially associated with ano-genital cancers [3]. Its predilection site for infection is stratified and squamous epithelium propagates as warty growths on the skin of genitalia and manifest dysplastic cellular proliferations. Over 100 subtypes of HPV are currently recognized, out of which 30 subtypes are found responsible for genital warts. Human Papillomavirus type 6, 11, 16, 18, 31, 33 and 35 are found responsible for clinical manifestation of genital warts (Figures 1 and 2). These are also associated with neoplasia, while, type 6 and 16 are strictly associated with cervical cancer in females [4]. Figure 1. Clinical representation of genital warts on scrotum. Corresponding author: Dr. Arsalan Khan, Livestock Research and Development Station, Paharpur, Dera Ismail Khan-29050, Pakistan, Tel: +92333-3143939; E-mail: drarsalankhandvm@gmail.com Citation: Khan A. (2019) Chemotherapy of Genital Warts. J Vet Marine Sci, 1(1): 15-17. Copyright: ©2019 Khan A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.