Fizazi et al Journal of Drug Delivery & Therapeutics. 2020; 10(5-s):51-56 ISSN: 2250-1177 [51] CODEN (USA): JDDTAO Available online on 15.10.2020 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research © 2011-18, publisher and licensee JDDT, This is an Open Access article which permits unrestricted non-commercial use, provided the original work is properly cited Open Access Research Article Sperm Profile of Infertile Men in the Western Region of Algeria: About 320 Cases Anissa FIZAZI 1 *, Malika BENDAHMANE 2 , Tewfik SAHRAOUI 1 1 Biology of Development and Differentiation Laboratory, Department of Biology, Faculty of Natural and Life Sciences, University of Oran1, Ahmed Ben Bella, Algeria 2 Laboratory of Research on Environment and Health (LRES), Faculty of Medicine, Hospital University of Sidi Bel Abbes, Algeria ABSTRACT Objective : The aim of this study is to describe the sperm profile and eventually determine the main spermatic disturbances at the origin of male infertility in western Algeria. Methods: We conducted a cross-sectional study in 320 infertile male patients consulting at the Medically Assisted Procreation Unit (MAP) of Oran, in Western Algeria, in the end of exploring the results of their semen analyses and semen culture. Results: The results of semen analysis revealed that the main spermatic disruption in our study was asthenospermia because at the first hour after emission, 93% of our patients had less mobility than normal. Oligospermia was present in 37% of cases and azoospermia in 14% of cases. That is, a concentration of sperm below normal in 51% of cases. Results of the analysis of the sperm’s morphological characteristics revealed that only 16% of our patients had teratospermia. The semen culture revealed that the main pathogen found in our patients is Staphylococci in nearly 70% of cases. Conclusion: Our study revealed alterations in both quantitative and qualitative semen of patients. This was mainly asthenospermia in 93% of cases followed by oligospermia. Keywords: Male infertility, Semen analysis, Semen culture, Western Algeria. Article Info: Received 07 Aug 2020; Review Completed 13 Sep 2020; Accepted 18 Sep 2020; Available online 15 Oct 2020 Cite this article as: Fizazi A, Bendahmane M, Sahraoui T, Sperm Profile of Infertile Men in the Western Region of Algeria: About 320 Cases, Journal of Drug Delivery and Therapeutics. 2020; 10(5-s):51-56 http://dx.doi.org/10.22270/jddt.v10i5-s.4426 *Address for Correspondence: Anissa FIZAZI, Biology of Development and Differentiation Laboratory, Department of Biology, Faculty of Natural and Life Sciences, University of Oran1, Ahmed Ben Bella, Algeria INTRODUCTION What defines infertility, according to the World Health Organization (WHO), is the absence of pregnancy after at least 12 months of regular and unprotected sexual intercourse 1 . Infertility affects around 15% of couples worldwide 2 . Epidemiological data suggests that roughly 48.5 million of couples having regular sexual intercourse suffer from it in the world 3 . Infertility rates in Africa are the highest in the world: it would affect between 15% and 30% of couples, against 5% to 10% in Europe 4 . Men are the only responsible of infertility in 20 to 30% of cases, and contribute to 50% of mixed infertility cases 5 . We speak of male infertility in the presence of poor quantity, mobility, morphology or functioning of sperm 6 . A man of the 2000’s produces half the sperm of his own father, a decrease of 2% per year 7 . The assessment of male infertility lies on a series of examinations; the semen examination proves to be a very good basic examination, allowing not only to make diagnoses, but also to direct the prescriber to additional examinations 8 . We estimate Algeria’s infertility rate at 15%, and the men are the cause of this infertility in more than half of the cases 9 . However, there is unfortunately a great lack of data and studies on male infertility in Algeria. In this context, we have conducted a study in order to describe the sperm profile in western Algeria and eventually