479 Hetti Rusmini, etal, The effect of honey (Ceiba pentandra) to Low Density Lipid level of male rats (Rattus norvegicus) that has been given high fat diet, jiksh Vol.11 No.1 Juni 2020 Jurnal Ilmiah Kesehatan Sandi Husada hhttps://akper-sandikarsa.e-journal.id/JIKSH Vol 11, No, 1, Juni 2020, pp;479-489 p-ISSN: 2354-6093 dan e-ISSN: 2654-4563 DOI: 10.35816/jiskh.v10i2.331 ARTIKEL PENELITIAN Pengaruh Madu Ceiba Pentandra Terhadap Kadar LDL Tikus Rattus Norvegicus Yang Diberi Diet Tinggi Lemak The effect of honey (Ceiba pentandra) to Low Density Lipid level of male rats (Rattus norvegicus) that has been given high fat diet Hetti Rusmini 1 , Devita Febriani 2 , Hidayat 3 , Dhani Risandy 4 1 Program Studi Kedokteran Fakultas Kedokteran Universitas Malahayati 2 Departemen Parasitologi Fakultas Kedokteran Universitas Malahayati 3 Departemen Farmakologi Universitas Malahayati 4 Departemen Patologi Klinik Universitas Malahayati Artikel info Artikel history: Received; Mei 2020 Revised: Juni 2020 Accepted; Juni2020 Abstract. Background: Hypercholesterolemia is a condition that body has increased cholesterol levels above normal threshold (<200 mg/dL). Hypercholesterolemia is the main risk factor for atherosclerosis which is the increase in Low Density Lipoprotein (LDL). Objectives: This study aims to determine the effect of Randu honey (Ceiba pentandra) on LDL levels of male rattus (Rattus norvegicus) strains given a high-fat-diet. Methodology: The type of research used is purely experimental using a pre-and-post test with group design. The population used in this study were 25 male Wistar strain rats which were divided into 5 groups. Sampling using the method of total sampling. Data were analyzed by Paired T-test and Anova. Research Results: From the 5 sample groups obtained the results of the analysis Paired T-Test, obtained a significant increase (p <0.05) of LDL levels after giving a high-fat-diet in the negative group (p = 0.025), treatment group 2 (p = 0.001), and treatment group 3 (p= 0.001). In the treatment after the administration of honey, there was a significant decrease (p <0.05) of LDL levels in 2 groups, namely in the treatment group 2 (p = 0.026), and the treatment group 3 (p = 0.092). With Anova analysis, a significant difference was found in the treatment after the administration of a high-fat diet and after the provision of honey honey with the same p value, namely p = 0.001 (P <0.05). Conclusion: There are differences that influence the administration of honey honey on LDL levels in wistar strain rats given a high-fat diet. Abstrak. Latar Belakang: Hiperkolesterolemia adalah suatu kondisi tubuh yang mengalami peningkatan kadar kolesterol di atas ambang normal (<200 mg/dL). Hiperkolesterolemia merupakan faktor risiko utama terjadinya arterosklerosis dengan salah satunya adanya kenaikan Low Density Lipoprotein (LDL). Tujuan Penelitian: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian madu