Supporting information Nonhierarchical Flux Regulation Exposes the Fitness Burden Associated with Lactate Production in Synechocystis sp. PCC6803 Wei Du †# , S. Andreas Angermayr †§# , Joeri A. Jongbloets † , Douwe Molenaar ‡ , Herwig Bachmann ‡ , Klaas J. Hellingwerf † and Filipe Branco dos Santos † * † Molecular Microbial Physiology Group, Faculty of Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands. ‡ Systems Bioinformatics, Faculty of Earth and Life Sciences, Systems Bioinformatics, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands.