World Journal of AIDS, 2019, 9, 167-182 https://www.scirp.org/journal/wja ISSN Online: 2160-8822 ISSN Print: 2160-8814 DOI: 10.4236/wja.2019.94013 Dec. 10, 2019 167 World Journal of AIDS Casual Sex, Sex Work and Unprotected Sex among Men Who Have Sex with Men in the Human Papilloma Virus (HPV) Clinical Trial —North-West Region of Tshwane, South Africa Mildred R. Sebogodi 1 , Mmampedi Huma 1 , Mathilda M. Mokgatle 1* , Matsontso Peter Mathebula 2 , Maphoshane Nchabeleng 3 1 Department of Epidemiology and Biostatistics, School of Public Health, Sefako Makgatho Health Sciences University, Tshwane, South Africa 2 MECRU, School of Medicine, Sefako Makgatho Health Sciences University, Tshwane, South Africa 3 Department of Microbiology, School of Medicine, Department of Microbiology, Sefako Makgatho Health Sciences University, Tshwane, South Africa Abstract Background: The gap in the understanding of the context of the sexually transmitted infections (STIs) and risky behaviours among men who have sex with men (MSM) could lead to the development and implementation of in- appropriate interventions, which could exacerbate the rapid spread of STIs, especially HIV, among MSM. The aim of the study was to qualitatively assess the understanding of the STIs and the risky sexual behaviours of men who have sex with men in the North-West region of Tshwane. Methods: An ex- ploratory qualitative design was employed to assess the STIs and the risky sexual behaviour of the MSM population. The study participants were enrolled in an HPV clinical trial at MECRU, which is a clinical research unit at the Se- fako Makgatho Health Sciences University. Data collection occurred from September 2016 to May 2017. A convenience sampling method was used and n = 30 participants were selected. Face-to-face in-depth interviews were con- ducted on MSM 18 years and older, using a semi-structured interview guide. Thematic content analysis was used for data analysis, using NVivo version 10 software. Results: The mean age of the sample was 26 years, and the age range was 18 to 44 years. All were unmarried, and all of them came from townships, rural villages and informal settlements in the vicinity of the clini- cal research unit. The high-risk behaviours noted among the majority of the MSM in this study were having multiple sexual partners and exchanging How to cite this paper: Sebogodi, M.R., Huma, M., Mokgatle, M.M., Mathebula, M.P. and Nchabelen, M. (2019) Casual Sex, Sex Work and Unprotected Sex among Men Who Have Sex with Men in the Human Papilloma Virus (HPV) Clinical Trial —North-West Re- gion of Tshwane, South Africa. World Journal of AIDS, 9, 167-182. https://doi.org/10.4236/wja.2019.94013 Received: October 24, 2019 Accepted: December 7, 2019 Published: December 10, 2019 Copyright © 2019 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access