Copyright: © the author(s), publisher and licensee Technoscience Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited International Journal of Scientific Research in Science and Technology Print ISSN: 2395-6011 | Online ISSN: 2395-602X (www.ijsrst.com) doi : https://doi.org/10.32628/IJSRST218467 426 A Case Study of Assessment of Haemato-Biochemical Profile, Clinical Diagnosis and Therapeutic Management of Canine Monocytic Ehrlichiosis (Tropical Canine Pancytopenia) In A Male Doberman DOG Deepak Chandran 1* , Georgen G Edana 1 , Salini Varghese 2 , Ajin S Kumar 3 1* Assistant Professor, Department of Veterinary Sciences & Animal Husbandry, School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Tamil Nadu, India *Corresponding author, Email-ID : c_deepak@cb.amrita.edu 1, 2 BVSc & AH Scholar, Kerala Veterinary and Animal Sciences University, Kerala, India 3 Veterinary Doctor (BVSc & AH), Kerala, India Article Info Volume 8, Issue 4 Page Number : 426-434 Publication Issue July-August-2021 Article History Accepted : 20 July 2021 Published : 27 July 2021 ABSTRACT Ehrlichia canis is an obligate intracellular rickettsial agent that is transmitted by a brown dog tick called as Rhipicephalus sanguineus which is considered as the principal vector of this disease. A 3-year-old male Doberman dog weighing 25 kg is presented with the history of inappetence, fever, weakness, anemia, scanty feces, hemoglobinuria, shrunken eye ball with mild corneal opacity and reluctant to walk due to pain in the joints. Clinical examination revealed elevated rectal temperature of 104.30F, tachycardia, increased respiratory rate and pale mucous membrane. Blood and serum samples were collected for hematology and serum biochemistry respectively. On blood smear examination with Giemsa staining, Ehrlichia morulae were noticed in monocytes suggestive of Canine Monocytic Ehrlichiosis / Tropical Canine Pancytopenia. Keywords - Ehrlichiosis, Doberman, Monocytosis, Pancytopenia, Morula I. INTRODUCTION Canine ehrlichiosis is a tick borne, febrile, debilitating disease of dogs and wild canidae caused by Ehrlichia canis transmitted by the brown dog tick Rhipicephalus sanguineus. The infections are known to occur worldwide. The disease is also known as canine typhus, canine haemorrhagic fever, tracker dog disease, idiopathic haemorrhagic syndrome and tropical canine pancytopaenia (Ristic and Holland, 1993). Ehrlichia are obligate intracellular organism which differ from rickettsiae because they replicate in the phagosome of host cell whereas all Rickettsia, with one exception (C. burnetti) grow free within the cytoplasm (Mudaliar, 1944). Ehrlichia canis and other members of the genus Ehrlichia are minute organisms that stain dark blue to purple with Romanowsky stain and with Machiavello method they stain light red and brown-black with silver stain. Studies conclusively proved trans-stadial transmission where in larvae, nymphs and adults are able to transmit the disease.