September 2020 · Volume 9 · Issue 9 Page 3889 International Journal of Reproduction, Contraception, Obstetrics and Gynecology Yadav R et al. Int J Reprod Contracept Obstet Gynecol. 2020 Sep;9(9):3889-3891 www.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789 Case Report Synchronous endometrial and ovarian cancer: a rare presentation Reena Yadav, Nishtha Jaiswal*, Ruby Yadav, Manisha Kumar INTRODUCTION Synchronous primary tumor account for 0.5-1.7 % of all gynecological malignancies. 1 The most common 40%- 53% synchronous primary tumors of genital tract are ovarian and endometrial cancers. 2 Patients with synchronous endometrioid tumors of endometrium and ovary are generally younger, have low grade malignancy, and prognosis is better than other histologic types. 3-5 It is challenging diagnostically and therapeutically when there is similar histology. CASE REPORT A 38-year-old nulliparous woman presented with chief complain of irregular and prolonged bleeding of four months duration. She was obese with BMI 40 kg/m 2 . She was detected with hypothyroidism twenty years back, was hypertensive since 4 years and was recently diagnosed with diabetes mellitus. There was no history of white discharge per vaginum, hormonal pill intake, weight loss and bladder or bowel complaints. On abdominal examination a mass corresponding to 16-week size of uterus was felt. Vaginal examination suggested the mass was in the right adnexa with bulky uterus. The MRI report showed a well-defined, lobulated complex, solid cystic multiseptated mass measuring 8.8×7.7×8.8 cm in the right adnexa, and the uterus was bulky with indistinct endo-myometrial junction, with the left ovary visualized and normal. Endometrial biopsy was taken and histopathological examination was reported as endometrial adenocarcinoma. Amongst tumor markers CA 125 was 212.7U/l. Considering both ovarian and uterine malignancy with an unclear primary tumor, an exploratory laparotomy with peritoneal cytology, total abdominal hysterectomy, bilateral salpingo- oopherectomy, infracolic omentectomy and pelvic lymphadenectomy was performed. Intraoperatively the uterus was 6 to 8 weeks size and there was a 10×10 cm solid cystic mass arising from right ovary. The ascitic fluid cytology was negative for malignant cells. ABSTRACT Synchronous primary cancers are relatively uncommon in the general population. About 0.5 -1.7% of gynecological malignancies have synchronous primary cancer of female genital tract. Amongst the synchronous gynecological malignancies synchronous endometrioid carcinoma is most common and has good prognosis. Patients with synchronous endometrioid tumors of endometrium and ovary are usually younger, have low grade number, and their prognosis is better than other histologic types. The authors are presenting a case of 38 years old nulliparous obese woman with pain in abdomen and heavy menstrual bleeding for a duration of four months. The MRI pelvis was suggestive of well defined, lobulated, complex, solid cystic multiseptated lesion measuring 8.8×7.7×8.8 cm in right adnexa, with anteverted uterus, and a bulky indistinct emdomyometrial junction. Histopathology revealed synchronous endometrial carcinoma of both uterus and ovary. Keywords: Endometrial cancer, Ovarian cancer, Synchronous tumors Department of Obstetrics and Gynecology, Lady Hardinge Medical College, New Delhi, India Received: 06 July 2020 Accepted: 05 August 2020 *Correspondence: Dr. Nishtha Jaiswal, E-mail: nishtha.amu@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20203877