Case Report
Multidisciplinary Approach to Hepatic Metastases of
Intracranial Hemangiopericytoma: A Case Report and
Review of the Literature
Dimitrios K. Manatakis,
1
Spiridon G. Delis,
1
Nikolaos Ptohis,
2
Penelope Korkolopoulou,
3
and Christos Dervenis
1
1
Surgical Department, “Konstantopouleio” General Hospital, Nea Ionia, 14233 Athens, Greece
2
Interventional Radiology Department, “G. Gennimatas” General Hospital, 11527 Athens, Greece
3
1st Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Correspondence should be addressed to Dimitrios K. Manatakis; dmanatak@yahoo.gr
Received 16 December 2014; Accepted 7 May 2015
Academic Editor: Francesca Micci
Copyright © 2015 Dimitrios K. Manatakis et al. Tis is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Hemangiopericytoma is a rare primary tumor originating from Zimmerman’s pericytes, with signifcant metastatic potential.
Hepatic metastatic disease requires an aggressive approach by a multidisciplinary team of dedicated oncology specialists, to prolong
survival in selected patients. We report on a patient with recurrent hepatic metastases of grade II intracranial hemangiopericytoma
5 years afer initial treatment, managed by a stepwise combination of liver resection, radiofrequency ablation, and transarterial
embolization. Although metastatic disease implies hematogenous dissemination, long-term survival afer liver resection has been
reported and major hepatectomies are justifed in patients with adequate local control. Liver resections combined with transarterial
embolization are highly recommended, due to hypervascularity of the tumor.
1. Introduction
Noncolorectal, nonneuroendocrine hepatic metastases are a
diverse group of secondary liver neoplasias, exhibiting vari-
able clinical behavior and characteristics. Particularly in cases
of rare primary tumors, where limited datasets are available
and no ofcial guidelines are published, a multidisciplinary
team (MDT) approach is mandated, to provide comprehen-
sive assessment, consultation, and treatment.
We present our experience with a case of recurrent
hepatic metastases from an intracranial hemangiopericytoma
(HPC), managed by an MDT of oncologic surgeons, med-
ical oncologists, interventional radiologists, and dedicated
pathologists.
2. Case Presentation
A 23-year-old Caucasian male underwent a right tempo-
ral lobe glomus tumor excision. Seven years later he was
diagnosed with local recurrence and underwent two cran-
iotomies to achieve radical resection (Figure 1). Histopathol-
ogy revealed an HPC grade II. No adjuvant chemoradiother-
apy was instituted.
Five years afer the last intervention, he was admitted to
hospital due to diverticulitis and an incidental fnding ofa
small lesion in the body of T10 vertebra was demonstrated on
CT scans, as well as multiple, atypical, hypervascular lesions
in both liver lobes, the larger being 8 cm in diameter, initially
considered hemangiomas (Figures 2 and 3). Magnetic reso-
nance imaging, however, was consistent with metastatic HPC
lesions rather than benign hemangiomas. Although positron
emission tomography (PET) revealed strong uptake of the
contrast medium in the T10 lesion, no uptake in the liver was
documented. Tumor markers (CEA, FP, and Ca19-9) were
within normal limits.
A right hepatectomy plus radiofrequency ablation of one
lesion in the lef lobe was decided and the patient had
an uneventful postoperative course. Histopathology revealed
two tumors (8.7 cm and 3.8 cm) consisting of relatively bland
Hindawi Publishing Corporation
Case Reports in Oncological Medicine
Volume 2015, Article ID 214306, 5 pages
http://dx.doi.org/10.1155/2015/214306