International Journal of Community Medicine and Public Health | January 2017 | Vol 4 | Issue 1 Page 269 International Journal of Community Medicine and Public Health Bachani S et al. Int J Community Med Public Health. 2017 Jan;4(1):269-273 http://www.ijcmph.com pISSN 2394-6032 | eISSN 2394-6040 Case Report Varied presentations of gestational trophoblastic disease in Asian women: one year follow up Sumitra Bachani, Neha Pruthi, Sana Tiwari*, Pratima Mittal INTRODUCTION Gestational trophoblastic disease (GTD) comprises of a heterogeneous group of tumors arising from abnormal proliferation of trophoblasts in the placenta. GTD accounts for less than 1% of female reproductive system cancers and its incidence varies greatly between different parts of the world. 1 Incidence of GTD in Asia and South America is higher than reported in Europe and North America. 2-4 It can present itself any of the five clinicopathological forms: hydatidiform mole (complete and partial), invasive mole, choriocarcinoma, placental site trophoblastic tumour and epitheloid trophoblastic tumors. The last four constitute the gestational trophoblastic neoplasia. The hydatidiform mole is the most common form, representing 80 percent of cases of GTD. Complete hydatidiform moles are diploid and have no fetal tissue and no maternal DNA while, partial hydatidiform moles are triploid and have somefetal tissue. The incidence of partial moles is 3:1000 and complete mole is 1:1000 of normal pregnancies. 5 Invasive mole is a hydatidiform mole characterized by the presence of enlarged hydropic villi invading into the myometrium, vascular spaces or into extrauterine sites. In 10% to 15% of cases, hydatidiform moles may develop into invasive moles. 6 Choriocarcinoma is characterized by abnormal trophoblastic hyperplasia and anaplasia, absence of villi, hemorrhage and necrosis, with direct invasion into myometrium and vascular invasion resulting in its spread to distant sites. Relatively it is an uncommon condition. The incidence varies from 1 in 500 (India) to 1 in 50,000 pregnancies (Western countries). 7 Placental-site trophoblastic tumor (PSTT) is a very rare form of GTD that develops where the placenta attaches to ABSTRACT Gestational trohoblastic tumors are rare tumors which constitute less than 1% cancers of female reproductive system. They have varied presentations of which hydatidiform mole is most common. The incidence is higher in Asia and South America as compared to the rest of the world. We present a total of 5 cases of Gestational trophoblastic disease (GTD) constituting 12.2% of admissions in Gynaecology ward of a tertiary care hospital over one year. There are various risk factors which predispose to GTD include maternal age less than 20 years or more than 35 years, prior GTD, prior miscarriages, Asian ethnicity and blood group A. Commonly the woman presents with vaginal bleeding in first trimester. Sonography and β-hCG are decisive in establishing the diagnosis and further management. Follow up of the patient is very crucial. Early diagnosis and timely management results in good prognosis. Keywords: Choriocarcinoma, β-Hcg, Invasive mole, Molar pregnancy Department of Obstetrics and Gynaecology, VMMC and Safdarjung Hospital, New Delhi, India Received: 08 November 2016 Accepted: 03 December 2016 *Correspondence: Dr. Sana Tiwari, E-mail: drsanatiwari89@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20164751