International Journal of Public Health Science (IJPHS) Vol. 10, No. 3, September 2021, pp. 558~564 ISSN: 2252-8806, DOI: 10.11591/ijphs.v10i3.20777  558 Journal homepage: http://ijphs.iaescore.com The antihyperlipidaemic and hepatoprotective effect of Ipomoea batatas L. leaves extract in high-fat diet rats Nurkhasanah Mahfudh, Nanik Sulistyani, Muhammad Syakbani, Athifah Candra Dewi Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia Article Info ABSTRACT Article history: Received Dec 20, 2020 Revised May 20, 2021 Accepted Jun 13, 2021 The administration of high-fat diets can increase the body's lipid level and damage the organs. Purple sweet potato leaf (Ipomoea batatas L.) was reported as an antioxidant against free radicals. This study aimed to observe the sweet potato leaf extract's activity on decreasing lipid profile and hepatoprotective effect in high-fat diet fed rats. The treatment animals were divided into five groups, namely normal control, high-fat diet (HFD) control, the treatment group of purple sweet potato leaf extract (SPLE) doses 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BW which fed with high-fat diet for 14 days and SPLE for 28 days. After treatment was completed, the blood was collected for the detection of cholesterol, triglyceride, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamic pyruvate transaminase (SGPT). After that, the animals were sacrificed, and a liver histopathology observation was conducted using Haematoxylien and Eosin staining. The result showed a significant decrease in cholesterol and triglyceride levels (p≤0.05) compared to the negative group in all treated groups. The SGOT and SGPT enzymes in all of treatment groups were also found to decrease compared with HFD control. The result was confirmed by the histopathological observations. The finding suggested the potency of SPLE for antihyperlipidaemic and hepatoprotective agent. Keywords: Ipomoea batatas L. Cholesterol Triglyceride SGOT SGPT This is an open access article under the CC BY-SA license. Corresponding Author: Nurkhasanah Mahfudh Faculty of Pharmacy Universitas Ahmad Dahlan Jl. Prof. Soepomo, Janturan, Yogyakarta, Indonesia Email: nurkhasanah@pharm.uad.ac.id 1. INTRODUCTION Hyperlipidemia is characterized by increased levels of total cholesterol, low density lipoprotein (LDL), triglycerides, and decreased high density lipoprotein (HDL). The high levels of blood lipids are well known as risk factors for cardiovascular disease [1]. The high level of lipid in the bloodstream has occurred following the high-fat diet. The small intestine absorbs fat from the diet and transfers it into chylomicrons, which are sent to peripheral tissues via the bloodstream [2]. The previous study found that elevated lipid levels were associated with increased liver enzymes [2], [3]. A high-fat diet can cause liver function disorders, which occurred by the accumulation of fat in the liver's hepatocytes, caused by an imbalance between the production and secretion of triglycerides by the liver. The increase in the liver's fatty acids beyond its capacity will trigger free radicals and lead the liver cell damage. One of the liver cell damage markers is the increase of SGOT and SGPT in the blood [4]. The leaves of purple sweet potato (Ipomoea batatas L.) were interesting to be studied. The previous report showed that giving Ipomoea batatas L extract can reduce cholesterol, triglyceride levels, and increase