186 JMPF Vol 10(3), 2020 | DOI : 10.22146/jmpf.53312 JMPF Vol. 10 No. 3 : 186-194 ISSN-p : 2088-8139 ISSN-e : 2443-2946 Evaluasi Penggunaan Aspirin Jangka Panjang terhadap Fungsi Ginjal Pasien Penyakit Jantung Koroner Evaluation of Long-Term Use of Aspirin on Kidney Function of Coronary Heart Disease Patients Ema Pristi Yunita 1,2* , Puji Astuti Nur Hidayanti 3 , Cholid Tri Tjahjono 4 1. Jurusan Farmasi, Fakultas Kedokteran, Universitas Brawijaya 2. Pusat Studi Molekul Cerdas Berbasis Sumber Genetik Alami (SMONAGENES), Universitas Brawijaya 3. Program Studi Sarjana Farmasi, Fakultas Kedokteran, Universitas Brawijaya 4. Departemen Kardiologi, Fakultas Kedokteran, Universitas Brawijaya, RSUD Dr. Saiful Anwar Submitted: 09-01-2020 Revised: 30-06-2020 Accepted: 28-09-2020 Korespondensi : Ema Pristi Yunita : Email : emapristi@ub.ac.id ABSTRAK Aspirin dosis-rendah (75-100 mg/hari) adalah terapi antiagregasi platelet bagi pasien penyakit jantung koroner (PJK) tertentu yang diberikan jangka panjang. Penelitian ini bertujuan untuk mengevaluasi penggunaan aspirin jangka panjang terhadap fungsi ginjal dengan melihat perubahan kadar kreatinin serum, blood urea nitrogen (BUN), dan klirens kreatinin pasien PJK. Metode penelitian yang digunakan yaitu analisis observasional kohort secara prospektif. Jumlah subjek penelitian yang memenuhi kriteria inklusi dan eksklusi sebanyak 37 pasien PJK pengguna aspirin dosis 80 mg/hari tanpa riwayat penyakit ginjal. Dilakukan pemeriksaan kadar kreatinin serum dan BUN pada bulan ke-1 dan bulan ke-3 dimulainya penelitian. Nilai klirens kreatinin pasien dihitung menggunakan rumus Cockcroft-Gault. Berdasarkan hasil penelitian, diperoleh rerata kadar kreatinin serum, BUN, dan klirens kreatinin pada bulan ke-1 dan bulan ke-3 masing-masing sebesar 1,03 ± 0,27 mg/dL dan 1,03 ± 0,29 mg/dL; 13,05 ± 4,10 mg/dL dan 14,65 ± 4,44 mg/dL; 73,16 ± 18,14 mL/menit dan 72,92 ± 19,76 mL/menit. Hasil uji t berpasangan menunjukan bahwa perbedaan rerata kreatinin serum, BUN, dan klirens kreatinin bulan ke- 1 dan bulan ke-3 tidak signifikan secara statistik (p > 0,05). Hasil uji One Way ANOVA tentang pengaruh durasi penggunaan aspirin terhadap fungsi ginjal juga tidak signifikan secara statistik (p > 0,05) namun terdapat kecenderungan penurunan klirens kreatinin serta peningkatan kreatinin serum dan BUN. Penggunaan aspirin dosis-rendah dalam jangka panjang berpotensi menyebabkan penurunan fungsi ginjal jika dilihat dari adanya penurunan nilai klirens kreatinin serta peningkatan kreatinin serum dan BUN. Kata kunci: Aspirin dosis-rendah; BUN; kreatinin serum; penyakit jantung koroner ABSTRACT Low-dose aspirin (75-100 mg/day) is a long-term platelet antiaggregation therapy for certain coronary heart disease (CHD) patients. This study aims to evaluate the long-term use of aspirin on kidney function by examining the changes in the levels of serum creatinine, blood urea nitrogen (BUN), and creatinine clearance of CHD patients. The research method used was a prospective observational cohort analysis. The number of study subjects was 37 CHD patients who took 80 mg/day of aspirin and never experienced kidney disease. Serum creatinine and BUN levels were examined in the 1 st and 3 rd month of the study. Patient creatinine clearance values were calculated using the Cockcroft-Gault equation. The results of the study showed that the mean levels of serum creatinine, BUN, and creatinine clearance on the 1 st and 3 rd month were 1.03 ± 0.27 mg/dL and 1.03 ± 0.29 mg/dL; 13.05 ± 4.10 mg/dL and 14.65 ± 4.44 mg/dL; 73.16 ± 18.14 mL/min and 72.92 ± 19.76 mL/min, respectively. The paired t-test results showed that the differences in the mean of creatinine serum, BUN, and creatinine clearance on the 1 st and 3 rd month were not statistically significant (p > 0.05). The One Way ANOVA test results on the effect of the duration of aspirin use on kidney function were also not statistically significant (p > 0.05) however there is a tendency to decrease creatinine clearance and increase in serum creatinine and BUN. Long-term use of low-dose aspirin has the potential to cause a decrease in kidney function that is seen from a decrease in creatinine clearance as well as an increase in serum creatinine and BUN. Keywords: Low-dose aspirin; BUN; serum creatinine; coronary heart disease