*Corresponding author, e-mail : nagina17001@mail.unpad.ac.id (N. Belali) https://doi.org/10.24198/idjp.v1i3.23491 © 2019 Belali et al Vol 1, Issue 3, 2019 (99-104) http://journal.unpad.ac.id/idjp Solvent Evaporation as an Efcient Microencapsulating Technique for Taste Masking in Fast Disintegrating Oral Tablets Nagina G. Belali 1,2* , Anis Y. Chaerunisaa 2 1. Department of Pharmaceutics, Faculty of Pharmacy, University of Kabul - Afganistan 2. Department of Pharmaceutics, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia Received: 4 Sep 2019/Revised: 30 Sep 2019/Accepted: 30 Sep 2019/Published: 1 Oct 2019 ABSTRACT Microencapsulation is an extensively used technology of present era, that has been applied to various felds like pharmaceutical industry, agriculture, cosmetics and food technology. With the help of which liquid or solid material can be encapsulated inside a polymeric coating flm for various reasons such as taste masking, control release and enhancing stability and etc. Microencapsulation can be achieved with diferent approaches and methods but one of the popular and frequently used feasible method is Solvent evaporation. Solvent evaporation is based on emulsifcation, solvent evaporation and extraction of microspheres, recently many variations have been made in this technology to improve the yield and properties of microspheres. Solvent evaporation has been widely used in microencapsulating for diferent purposes one of which is taste masking of bitter drugs in fast disintegrating oral tablets, for pediatric and geriatric use. FDTs are center of attraction due to their merits and feasibility of use for people with problem of dysphagia at the same time, it can also improve bioavailability and time of action of drugs. The main focus of current review is use of solvent evaporation technique for taste masking of bitter drugs in production of fast disintegrating oral tablets. In this review, we will summarize uses, novelties and variations in Solvent Evaporation technique, preparation technique, materials used, merits and demerits of this method over other microencapsulation method in taste masking. Keywords: Microencapsulation, Solvent Evaporation, FDTs, extraction, microspheres 1. Introduction In last decade many novelties and development has been shown up in feld of pharmaceutics, one of which is encapsulation of drugs that can be done on nano and micro scale. However, Microencapsulation is a technique that has been used for several decades, it’s a term that present microspheres with a size of 1µm or less, liquid or solid particles encapsulated with a secure external layer that ofers merits such as control drug release, better drug efcacy, better bioavailability, better drug stability, and low toxicity. [1] Till now diferent techniques have been used for microencapsulation such as solvent evaporation, spray drying, polymerization, coacervation, and phase separation and most of them have been applied in production of fast disintegrating oral tablets, [2] for example oxalic acid was microencapsulated by coacervation method [3] also metformin hydrochloride was microencapsulated with same approach of coacervation as sited in [4], taste masked ofoxacin microspheres by solvent evaporation,[5] microencapsulation of antioxidant compounds from black berry [6] microencapsulation of carotenoids [7], moreover taste masked microspheres of famotidine that were applied in preparation of famotidine orally disintegrating tablets, reported by Jiachen Xu [8] were also prepared by spray drying approach, trioctylmethylammonium chloride (TOMAC) microencapsulation was reported to be performed by suspension polymerization technique as narrated by [9]. 2. Solvent evaporation technique Solvent evaporation is a frequently used in fabrication of micro and nanoparticles, moreover it has been used in fabrication of hydrophobic lipid