Volume 113 Clinical and laboratory observations 7 0 3 Number 4 tive study of unexplained nausea and vomiting after marrow transplantation. Transplantation 1986;42:602-7. 4. Spencer GD, Shulman HM, Myerson D, Thomas ED, McDonald GB. Diffuse intestinal ulceration after marrow transplantation: A clinicopathologic study of 13 patients. Hum Pathol 1986;17:621-33. 5. Pass RF, Whitley RJ, Diethelm AG, Whelchel JD, Reynolds DW, Alford CA. Cytomegalovirus infection in patients with renal transplants: Potentiation by antithymocyte globulin and an incompatible graft. J Infect Dis 1980;142:9-17. 6. Converse P, Hess A, Tutschka P, Santos GW. Effect of cyclosporineon the responseof normal human lymphocytes to cytomegalovirus in vitro. Infect Immun 1983;41:1226-33. 7. Chachoua A, Dieterich D, Krasinski K, et al. 9-(1,3-dihydro- xy-2-propoxymethyl) guanine (gancyclovir) in the treatment of cytomegalovirusgastrointestinal disease with the acquired immunodeficiency syndrome. Ann Intern Med 1987;107:133- 7. 8. Weber JN, Thorn S, Barrison I, et al. Cytomegaloviruscolitis and oesophageal ulceration in the context of AIDS: Clinical manifestations and preliminary report of treatment with Foscarnet (phosphonoformate). Gut 1987;28:482-7. 9. Rakela J, Wiesner RH, Taswell HF, et al. Incidence of cytomegalovirusinfection and its relationship to donor-recip- ient serologic status in liver transplantation. Transplant Proc 1987;19:2399-2402. 10. Snydman DR, Werner BG, Heinze-Lacey B, et al. Use of cytomegalovirusimmune globulin to prevent cytomegalovirus disease in renal-transplant recipients. N Engl J Med 1987;317-1049-54. A unique association of short stature, dysmorphic features, and speech impairment (Floating-Harbor syndrome) Pat L. Robinson, MD, Mordechai Shohat, MD, Robin M. Winter, MD, William J. Conte, MD, David Gordon-Nesbitt, MD, Murray Feingold, MD, Zvi Laron, MD, and David L. Rimoin, MD, PhD From the Division of Medical Genetics, Harbor/University of California at Los Angeles Medical Center, the Kennedy Galton Center for Clinical Genetics, Los Angeles, the Kennedy Memorial Hospital, Boston, the institute of Pediatric Endocrinoiogy, Beilinson Medical Center, the Department of Pediatrics, Distinct General Hospital, Stanford, England, and the Medical Genetics-Birth Defects Center, Cedars-Sinai Medical Center, University of California at Los Angeles Sctlool of Medicine In 1973, Pellietier and FeingoldI described a 5 89 boy with short stature, a peculiar facies, and delayed speech development. The child was seen at Boston Floating Hospital. Almost identical facial features and strikingly similar clinical findings were observed in a 9-year-old boy who was seen at Harbor General Hospital, Torrance, Calif. The authors of the report of this second child suggested the term "Floating-Harbor syndrome" (from the names of the hospitals where the patients were evaluated) to describe this apparently new syndrome.2 Subsequently, four girls with similar clinical features have come to our attention. All these children have short stature (at least 4 SD below Supported in part by U.S. Public Health Service NIH program project grant HD-22657 and postdoctoral research training grant GM-08243 and by the SHARE Child Disability Center. Submitted for publication Jan. 25, 1988; accepted April 26, 1988. Reprint requests: David L. Rimoin, MD, PhD, Division of Medical Genetics, Department of Pediatrics, Cedars-Sinai Medi- cal Center, Box 48750, Los Angeles, CA 90048-0750. the mean for age), with a marked delay in bone age and normal endocrine evaluation. Their facies are strikingly similar, and all had significant impairment of verbal skills. This report will summarize the clinical features shared by these six unrelated patients, who appear to represent a unique clinical entity. CLINICAL FEATURES The clinical features are summarized in the Table. Two of the individuals had French-Canadian ancestry, and the others were British, Iranian, or Israeli. The parents of patient 4 were from Iranian families in which intermar- riage had occurred. This patient was the product of a third-cousin mating (coefficient of inbreeding is 1/256). With the exception of fetal distress before delivery in two of the patients, the pregnancy histories were normal. Prenatal onset of short stature was noticed in five of the patients. Although two had low birth weight (<2500 gm), in most cases the birth weight was less affected than the