S40 Monday, 10 December 2007 1.125 Non-motor symptoms clustering in Parkinson’s disease: The PRIAMO study C. Colosimo 1° , PRIAMO study group 1 Rome, Italy Objective: A variety of non-motor symptoms (NMS), including gastroin- testinal, urogenital, psychiatric, sleep, respiratory, skin, attention/memory disturbances, adversely impact on Parkinson’s disease (PD) quality of life. We have assessed how NMS are related in a large sample of Italian PD patients from the PRIAMO study. Method: PRIAMO is a 2-yrs ongoing longitudinal observational study that enrolled 1072 PD patients from 55 centers widely distributed through- out Italy. Clinical diagnosis of PD was performed according to the current diagnostic criteria. All patients underwent a clinical examination. Each NMS was evaluated by a structured interview. We used factor analysis (using varimax rotation) to group NMS. A cut-off of 0.35 for factor loadings was used in order to define NMS grouping. Clinical judgment validated the statistical procedure. Results: A total of 48 different NMS were assessed. Factor analysis revealed 17 factors accounting for 53.3% of total variance. The first factor (10% of total variance) was composed by lost interest in activities of daily living (prevalence: 21%) or in surrounding matters (20%), anhedo- nia (11%), awareness deficit (4%), fatigue (58%). Factor 2 (4% of total variance) was composed by “forget to do daily things” (prevalence: 9%), “forget conversations done a short time ago” (25%), “difficulties to keep concentration” (31%). 693 (65%) and 479 (45%) patients complained of at least one symptom of that included in factor 1 and factor 2 respectively. Conclusion: The investigated NMS seem to have a scattered structure with a small proportion of accounted variability, although behavioral and cognitive features may develop concomitantly. Study supported by an unrestricted grant by Boehringer Ingelheim, Italy. 1.126 Non-motor symptoms in akinesia dominant versus other phenotypes in Parkinson’s disease (PD): Results form the international PD non-motor symptoms scale study Y. Naidu 1° , D. Contrafatto, P. Martinez-Martin, K.R. Chaudhuri 1 London, United Kingdom Objective: Parkinson’s disease (PD) can be separated to three different motor patterns: Tremor type (TT), Akinetic-Rigid type (ART) and Mixed type (MT). In this study generated from the international validation study of the recently reported PD non motor symptoms scale (NMSS), we report on the burden of non-motor symptoms and health related quality of life (HrQol, using the Parkinson’s disease Questionnaire-8 items (PDQ-8)) in these different subgroups of PD. Method: 239 PD patients (137 male, 102 female) were studied; 44 patients (18.4%) have a TT disease, 71 (48.1%) have an ART and 124 (51.88%) a MT. Subjects completed the nine domains, 30 items NMSS, a grade rating scale (Chaudhuri et al. Mov Disord 2007; DOI: 10.1002/mds.21596). Since the population presented a “non-normal” dis- tribution pattern, non parametric tests were used. Results: Sex (p 0.257) and distribution among the Hoehn–Yahr stages (p 0.135) didn’t significantly differ. No significant differences in PDQ- 8 score (p 0.124) was found, but there was the trend for ART to have higher PDQ-8 while NMSS total score was borderline significantly higher in ART patients (p 0.04). However, combining the RT and MT patients (n 168, 70.29%) versus the AR subjects, NMSS score was significantly worse in ART (63.81±38.74 vs 53.44±41.14, p 0.016) and additionally, with worse PDQ-8 scores (33.34±19.04 and 28.34±18.57, p 0.045). There were no differences in age, sex, duration of disease and UPDRS although ART patients were older then non ART subjects at the onset of disease (63.28±12.88 and 59.43±12.36 respectively, p 0.03). Conclusion: Our data suggest that the burden of non-motor symptoms complex as a whole is higher in Akinetic type PD patients. This appears to have a negative impact on health related quality of life. 1.127 Spontaneous observation saccades in Parkinson’s disease J. Sienkiewicz 1° 1 Warsaw, Poland Objective: The function of brain stem saccades generator is preserved in idiopathic Parkinson’s disease (PD). This results in normal saccadic velocity and constant ratio between amplitude and velocity. The measurement of saccadic velocity is sensitive tool to detect parkinsonism “plus” syndromes (multiple system atrophy, spinocerebellar ataxias, progressive supranuclear palsy). Some kinds of saccadic eye movement are impaired (memory guided, saccades on demand) and some are not (predictive, visually guided) in PD. The aim of study was to compare performance of saccadic eye movement during spontaneous observation in patients with idiopathic Parkinson’s disease (PD) and in healthy subjects. Method: Spontaneous observation saccades of approximately 25º am- plitude were generated by visual task (distinguishing pairs of figures placed horizontally). In another part of examination subjects performed 25º horizontal saccades on demand toward objects presented on the screen. Infrared oculography was applied. We evaluated number and percentage of multi-step saccades (fragmentation of large saccadic movement with inter- fixations present externally from the figure’s area). The study was extended by measurement of horizontal and vertical saccadic velocity and registration of saccades performed on demand. The examined group consisted of 27 PD patients (mean age 63.5±10.6; 42−79, mean disease duration 7.7±5.8; 1−20) and 33 healthy persons form the control group. Patients with dementia and abnormally slow saccadic velocity were excluded. Results: There was no significant difference in performance of large observation saccades in both examined groups. The percentage of multi- step saccades registered during observation task was similar in PD patients and in healthy subjects (11.2±6.3 vs 11.7±5.1). The frequency of multi- step saccades performed on demand was significantly higher in patients group (30.7±12.4% vs 12.1±8.9%; p < 0.005). Conclusion: Voluntary active observation seems to generate normal saccadic performance in parkinsonian patients. 1.128 Are there multisensory defcits in early Parkinson’s disease? A case-control study V. Pieri 1° , M. Vaillant, S. Blyth, G. Hipp, N.J. Diederich 1 Luxembourg-City, Luxembourg Objective: To investigate if patients with early Parkinson’s disease (PD) have multisensory deficits. Hyposmia has been described as premotor PD sign [1]. Visual abnormalities have been found in early PD stages [2]. There is no study comparing simultaneously both sensory systems in early PD patients versus controls. Method: We prospectively recruited 22 patients with early PD disease (mean = 2.33±1.17 years) and compared with 19 healthy age-matched controls. We tested: olfaction (UPSIT, 40 items), primary vision including color discrimination (Lanthony D-15 Test and Farnsworth-Munsell 100 Hue Test) and contrast perception (Vis-Tech and Pelli-Robson), and higher visual functions (VOSP; Visual object and space perception). Statistical analysis was performed, using Chi2 and ANOVA. Results: Age, gender, educational level and cognitive functioning showed no difference between both groups. PD patients performed less well than the controls in the UPSIT test (21.65±5.29 versus 28.89±6.4; p < 0.001) and in the primary vision tests: Farnsworth-Munsell 100 Hue test (283.3±55.15 versus 234.6±35.29; p < 0.001), binocular Pelli-Robson (1.23 ±0.27 versus 1.29 ± 0.29; p = 0.03), Vis-Tech 1.5, 3 and 6 cpd (p = 0.01, respectively 0.02, and 0.02). There was no difference for the VOSP. Conclusion: Non-demented early PD patients have both, olfaction and vision deficits, when compared to age-matched controls. These findings suggest that subtle non motor signs start synchronously at different levels. We presently investigate other non-motor signs in early PD patients (see