1 Probability of cancer in lung nodules using sequential volumetric screening up to 12 months: UKLS trial. Marcus MW 1 , Duffy SW 2 , Devaraj A 3 , Green BA 1 , Oudkerk M 4 , Baldwin DR 5 , Field JK 1 . 1 Roy Castle Lung Cancer Research Programme, the University of Liverpool Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, the University of Liverpool. Liverpool L3 9TA, UK. 2 Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ 3 Royal Brompton and Harefield NHS Foundation Trust, London, UK. 4 University of Groningen, University Medical Center Groningen, Center for Medical Imaging EB 45, Hanzeplein 1, 9700RB Groningen, Netherlands 5 Department of Respiratory Medicine, Nottingham University Hospitals, Nottingham, UK Corresponding authors: Professor John K Field Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool William Henry Duncan Building 6 West Derby Street Liverpool L7 8TX UK Email: J.K.Field@liverpool.ac.uk Dr. Michael W. Marcus Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool William Henry Duncan Building 6 West Derby Street Liverpool L7 8TX UK Email: m.w.marcus@liv.ac.uk Word count Abstract: 249