1 SUPPLEMENTARY INFORMATION Biosynthesis and heterologous production of argyrins Domen Pogorevc ‡ a , Ying Tang ‡ a,b,c , Michael Hoffmann a,d , Gregor Zipf e , Hubert S. Bernauer e , Alexander Popoff a , Heinrich Steinmetz f , Silke C. Wenzel a* a Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) / Helmholtz Centre for Infection Research (HZI) and Department of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbruecken, Germany b Hunan Provincial Key Laboratory of Microbial Molecular Biology, State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha 410081, People's Republic of China c current address: School of Basic Medical Science, Changsha Medical University, Changsha, PR China d current address: BASF SE, 67056 Ludwigshafen am Rhein, Germany e ATG:biosynthetics GmbH, 79249 Merzhausen, Germany f Microbial Strain Collection, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany ‡ These authors contributed equally. * Corresponding author. Phone: +49 681 30270221. Email address: s.wenzel@mx.uni-saarland.de