Journal of Biomaterials and Nanobiotechnology, 2016, 7, 109-117 Published Online April 2016 in SciRes. http://www.scirp.org/journal/jbnb http://dx.doi.org/10.4236/jbnb.2016.72012 How to cite this paper: Al Mualla, S., Farahat, R., Basmaji, P., de Olyveira, G.M., Costa, L.M.M., da Costa Oliveira, J.D. and Francozo, G.B. (2016) Study of Nanoskin ECM-Bacterial Cellulose Wound Healing/United Arab Emirates. Journal of Bioma- terials and Nanobiotechnology, 7, 109-117. http://dx.doi.org/10.4236/jbnb.2016.72012 Study of Nanoskin ECM-Bacterial Cellulose Wound Healing/United Arab Emirates Saqer Al Mualla 1 , Raed Farahat 1 , Pierre Basmaji 2 , Gabriel Molina de Olyveira 3* , Ligia Maria Manzine Costa 4 , José Domingos da Costa Oliveira 2 , Gino Bruno Francozo 2 1 Al Qassimi Hospital/Kuwait Hospital, Sharjah, United Arab Emirates 2 Innovatec’s-Biotechnology Research and Development, São Carlos, Brazil 3 Department of Physical Chemistry, Universidade Estadual Paulista (UNESP), Araraquara, Brazil 4 Materials Engineering Department, São Carlos School of Engineering, University of São Paulo, São Carlos, Brazil Received 11 March 2016; accepted 26 April 2016; published 29 April 2016 Copyright © 2016 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/ Abstract Natural extracellular matrices (ECMs) perform the tasks necessary for tissue formation, mainten- ance, regulation and function, providing a powerful means of controlling the biological perfor- mance of regenerative materials. In addition, biomedical materials have claimed attention be- cause of the increased interest in tissue engineering materials for wound care and regenerative medicine. Moreover, the nanostructure and morphological similarities with collagen make BC at- tractive for cell immobilization, cell support and Natural Extracellular Matrix (ECM) Scaffolds. In this work, we present the extracellular matrix (ECM) using the bacterial cellulose (Nanoskin ® ) which regulates cell behavior by influencing cell proliferation, survival, shape, migration and dif- ferentiation. Bacterial cellulose fermentation process is modified before the bacteria are inocu- lated for mimicking ECM to cells support and built new local material for wound healing. Chemical groups influences and thermal behavior in bacterial cellulose were analyzed using transmission infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), respectively. Besides, In vivo analysis was evaluated with clinical study at Sharjah Kuwait Hospital. Keywords Bacterial Cellulose (Nanoskin), Natural Nanocomposites, Regenerative Medicine, Stem Cells 1. Introduction Tissue engineering is a recent field that creates functioning artificial tissues and organs. Major considerations in * Corresponding author.