1 Supporting Information Synthesis, characterisation, molecular docking, biomolecular interaction and cytotoxicity studies of novel Ruthenium(II)-arene-2- heteroarylbenzoxazole complexes‡ Sourav De, a † Shreya Ray Chaudhuri, a † Arpita Panda, a Gajanan Rahosaheb Jadhav, a R. Selva Kumar, a Prasanth Manohar, b N. Ramesh, b Ashaparna Mondal, Anbalagan Moorthy, b Subhasis Banerjee, c Priyankar Paira, a * S. K. Ashok Kumar a * S. No Table of contents Page No Table S1 Photo physical properties of 4, 4', 5 and 5' benzoxazole based Ru(II) complexes 2 Table S2 Physical characteristics of complexes 2 Table S3 Molar conductivity study of the complexes Table S4 Binding energy of DNA-complexes and BSA-complexes calculated from Molecular docking studies (kcal mol -1 ) 2 Table S5-S9 Relative viscosity of CT-DNA interaction with Ru(II) based complexes (4, 4', 5 and 5') 2-3 Table S10 Selected bond lengths (Å) and bond angles (°) of complexes 3 Table S11 Calculated molecular electronic parameters 4 Figure S1 Emission spectra of 4, 4', 5 and 5' in DMSO and DMSO: water media 4 Figure S2 Solubility study of complexes 5-6 Figure S3 Stability examination of 4, 4', 5 and 5' complex in various medium (a) in water medium (b) MTT condition 6-7 Figure S4 Cell viability plot of complex 5 in HeLa cell line 7 Figure S5 DNA binding plot by UV-Vis spectral method for complex 8 Figure S6 Ethidium bromide displacement assay for complex 9-10 Figure S7 BSA binding plots for complex 10-11 Figure S8 Docking pose of compounds 4, 4', 5 and 5' within the minor groove of DNA 12 Figure S9 Docking pose of compounds 4, 4', 5 and 5' within the active site of BSA protein 12 Figure S10 Optimized structure of complex 13 Figure S11-S28 Characterisation of synthesized complexes 13-22 Electronic Supplementary Material (ESI) for New Journal of Chemistry. This journal is © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2019