SUMMARY Background/Aim: Congenital defects such as cleft palate and lips require a long-lasting and multidisciplinary approach. In cases when surgical and orthodontic treatment is not feasible, prosthodontic management of these patients is advocated. Prosthetic rehabilitation of cleft palate in concerning of achieving aesthetic and function (such as swallowing and speech) outcomes is very demanding. Case report: Material and method: After performing the necessary surgical procedures and orthodontic treatment, 24-years-old male patient was sent to the Department for Maxillofacial Prosthetics of Istanbul University. Followed the clinical examination, the necessary periodontal and conservative therapy was performed. After radiographic evaluation and dental cast analysis prosthetic rehabilitation was performed. The prosthetic rehabilitation of cleft palate was accomplish with conventional fixed partial denture whose number of included abutment were defined by biomechanical principles. Additionally removable partial denture were manufactured for closing oro-nasal defects and lip supporting. Conclusions: The prosthetic rehabilitation resulted with functionally and aesthetically content prosthesis. With achieving proper swallowing Quality of Life of the patient was enormously enhanced. Key words: Cleft Palate, Defect, Congenital, Andrew’s Bridge Almina Murić 1 , Demet Cagil Ayvalioglu 2 , Bilge Gokcen Rohlig 2 1 White Smile Private Dental Clinic, Podgorica, Montenegro 2 Departement of Prosthetic Dentistry, Faculty of Dentistry, Aydin University, İstanbul, Turkey CASE REPORT (CR) Balk J Dent Med, 2020;57-61 BALKAN JOURNAL OF DENTAL MEDICINE ISSN 2335-0245 Prosthetic Rehabilitation of Cleft Lip Palate with Andrews Bridge Modified as Obturator Prosthesis: Case Report S T O M A T O L O G I C A L S O C I E T Y Introduction Cleft of lip and palate is a type of craniofacial malformation that occurs by not fusing of two sides of maxilla during the embryonic stage 1 . The incidence of 9.92 per 10,000 live births classifies the cleft lip palate one of the most frequent congenital anomalies 2 . Clinically is presented as an irregular and incomplete maxillary growth and oro-nasal communication, accompanied with agenesis or malformation of the teeth which affect the function of swallowing and speaking. There are various classifications of cleft lip palate. According to Veau’s (the most commonly used) classification, all cleft lip palates can be evaluated in four main groups 3-5 . I. Clefts of the soft palate II. Clefts of the soft and hard palate, up to the incisive foramen III. Clefts of the soft and hard palate extending unilaterally through alveolus IV. Clefts of the soft and hard palate extending bilaterally through alveolus 1 . Rehabilitation of cleft lip palate is a very challenging task and require a multidisciplinary approach since the neonatal period. The aim of rehabilitation besides reestablishing aesthetic is to improve the function of speech of the patient and achieve adequate nutrition 6 . Due to a long and stressful treatment period, the patient should also be supported psychologically. Therefore the multidisciplinary approach including plastic surgeons, dentists, and psychologists will be beneficial 7 . The ideal treatment of cleft lip palate is surgical bone grafting and orthodontic positioning of the teeth. Surgical treatment most often consider shifting of retruded premaxilla in protruding position or achieving of complete closing of oro-nasal communication with bone grafting. 10.2478/bjdm-2020-0010