Case Report Incidentally Detected Kaposi Sarcoma of Adrenal Gland with Anaplastic Features in an HIV Negative Patient Zeliha Esin Celik, 1 Murat Celik, 2 Erdem Sen, 3 Hakan Cebeci, 4 Ozlem Ata, 3 and Cagdas Yavas 5 1 Pathology Department, Faculty of Medicine, Selc ¸uk University, Alaaddin Keykubat Campus, Selc ¸uklu, 42000 Konya, Turkey 2 Pathology Department, Faculty of Medicine, Selc ¸uk University, Turkey 3 Clinical Oncology Department, Faculty of Medicine, Selc ¸uk University, Turkey 4 Radiology Department, Faculty of Medicine, Selc ¸uk University, Turkey 5 Radiation Oncology Department, Faculty of Medicine, Selc ¸uk University, Turkey Correspondence should be addressed to Zeliha Esin Celik; dresincelik@hotmail.com Received 15 July 2016; Accepted 8 September 2016 Academic Editor: Atif A. Ahmed Copyright © 2016 Zeliha Esin Celik et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Kaposi sarcoma (KS), a vascular tumor caused by infection with human herpesvirus 8 (HHV8), is a systemic disease that can present with cutaneous lesions with or without visceral involvement. Very few cases of KS, most of which were associated with AIDS, have been reported in the adrenal gland. Anaplastic transformation of KS is a rare clinical presentation known as an aggressive disease with local recurrence and metastatic potential. We report here a 47-year-old HIV negative male presented with extra-adrenal symp- toms and had an incidentally detected anaplastic adrenal KS exhibited aggressive clinical course. To the best of our knowledge, this is the frst case of anaplastic primary adrenal KS without mucocutaneous involvement but subsequently developed other side adrenal metastases in an HIV negative patient. 1. Introduction Kaposi sarcoma (KS) is a rare low-grade malignant vascular neoplasm caused by human herpesvirus 8 (HHV8) and ofen occurs in the setting of human immunodefciency virus (HIV) infection [1]. KS is a multifocal tumor that manifests most frequently in mucocutaneous sites, typically the skin of the lower extremities, face, trunk, genitalia, and oropharyngeal mucosa [1, 2]. Visceral KS in the absence of mucocutaneous lesions is uncommon [3] and among viscera, adrenal gland involvement of KS is extremely rare with very few reports in the literature [2–6] many of which are usually associated with AIDS [1]. Anaplastic KS, which is defned histologically as a tumor with greater cytologic atypia and high mitotic rate, is accepted as a disease with a more locally aggressive behaviour and metastatic potential, but its exact incidence is indeterminate in the literature [1, 7]. Herein, we report a case of anaplastic primary adrenal KS without mucocutaneous involvement which is incidentally diagnosed in an HIV negative patient and exhibited aggres- sive clinical course with a metastatic tumor detected at the other adrenal gland seven months afer the initial diagnosis. 2. Case Report A 47-year-old male applied to a pulmonologist with com- plaint of cough. Torax computed tomography was per- formed and 8 × 6 × 3 cm mass was incidentally detected at lef adrenal gland on radiological sections. Ten, the patient was evaluated in terms of hormonal activity of the mass by endocrinologist with suspicion of pheochromocy- toma, Cushing syndrome, or hyperaldosteronism but the results were negative for each. Subsequently, a dynamic magnetic resonance imaging of lef adrenal gland was per- formed and T1-weighted enhanced images revealed difuse Hindawi Publishing Corporation Case Reports in Pathology Volume 2016, Article ID 1280201, 5 pages http://dx.doi.org/10.1155/2016/1280201