CLINICAL ARTICLE University of Pelita Harapan |133 Risk Factors of Cervical Cancer in Outpatient and Inpatient at Obstetric and Gynecology RSUP Dr. Mohammad Hoesin Palembang Monica Trifitriana 1 , Rizal Sanif 2 , Syarif Husin 3 , Rido Mulawarman 1 1 Medical Profession, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia 2 Department Obstetrics and Gynecology Faculty of Medicine, Sriwijaya University, Palembang, Indonesia 3 Department of Nutrition, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia Citation : Trifitriana M, Sanif R, Husin S, Mulawarman R. Risk Factors of Cervical Cancer in Outpatient and Inpatient at Obstetric and Gynecology RSUP Dr. Mohammad Hoesin Palembang Medicinus. 2019 February; 7(5):133–140 Keywords : Servical Cancer, Risk Factor, Palembang. *Correspondance : Monica Trifitriana, Medical Profession, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia E-mail : Monicatrifitriana@rocketmail.com Online First : June 2020 Abstract Introduction: Cervical cancer is a malignant tumor originating from primary squamous epithelial cells and it is one of the several types of cancers that affects more to women. Methods: This research uses descriptive analytic with case- control. The sample was 52 patients who divided into 26 patients with cervical cancer and 26 patients with non - cervical cancer were outpatient and inpatient at Department of Obstetrics and Gynecology Hospital Dr. Mohammad Hoesin Palembang during the period September 2016 -November 2016. This study uses primary data in the form of interviews. Data was analyzed by univariate and presented in a frequency distribution table. Furthermore, using bivariate analysis to determine the relationship and OR. Result: From 8 risk factors studied, there is sygnificancy correlation between pathological vaginal discharge (p= 0,0005 OR= ∞), parity (p= 0,0005 OR= 22,7), age (p= 0,0005 OR= 19,2), oral contraception usage for a long time (p= 0,0005, OR= 12,4), age of the first intercourse (p= 0,006, OR= 6,1 ), and the husband’s occupation (p= 0,05 OR= 3,6) with the incidence of cervical cancer. While, there are two risk factors that don’t have a sygnificancy correlation between smoking (p= 1,0) and changing sexual partners (p= 1,0) with the incidence of cervical cancer. Conclusion: The results of this research identified risk factors that significantly related to cervical cancer incidence was the age, the age of first sexual intercourse, parity, long-term oral contraceptive use, a history of vaginal discharge, and the husband's occupation. Introduction Cervical cancer is a primary cervical cancer originating from epithelial metaplasia in the columnar squamous junction region (SSK) which is a transitional area of the vaginal mucosa and cervical canal mucosa, where it is the second most common type of cancer affecting women worldwide, usually affecting women aged 35 -55 years.1 There are 270,000 women in the world every year diagnosed with cervical cancer and 85% are in developing countries including Indonesia 2 Cervical cancer is always followed by the HPV virus which is transmitted through sexual contact. It starts with precancerous lesions which after years can develop to be invasive. Although the main cause of cervical cancer is HPV infection, there are major risk factors for cervical cancer that can affect HPV infection, namely: Age, age of early sexual intercourse, smoking, high parity, long- term use of birth control pills, multiple sexual partners , vaginal discharge, and husband's work. These risk factors are very closely related to the occurrence of cervical cancer.