_____________________________________________________________________________________________________ *Corresponding author: E-mail: waseem_rad1@hotmail.com; Journal of Pharmaceutical Research International 33(42B): 166-171, 2021; Article no.JPRI.72814 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Impact of Gastric Acids on Surface Roughness of Dental Materials: A Systematic Review Waseem Radwan 1* , Iman El Mansy 2 , Aljohara Alyahya 3 , Mada Alawad 3 , Reem Alsaileek 3 and Sara Alyousef 3 1 Chairman of Restorative Department, Riyadh Elm University, Riyadh, Saudi Arabia. 2 Faculty, AEGD, Department of Restorative Dentistry, Riyadh Elm University, Riyadh, Saudi Arabia. 3 Dental Interns, Riyadh Elm University, Riyadh, Saudi Arabia. Authors’ contributions This work was carried out in collaboration among all authors. All authors made best contribution for the concept, assessment and evaluation, data acquisition and analysis and interpretation of the data All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i42B32436 Editor(s): (1) Dr. Syed A. A. Rizvi, Nova Southeastern University, USA. Reviewers: (1) Viviana Yolanda Flores, National University of Córdoba, Argentina. (2) Nagat Hassan Bubteina, Benghazi University, Libya. (3) Iacov-Craitoiu Monica-Mihaela, University of Medicine and Pharmacy of Craiova, Romania. (4) Juhi Yadav, Allopathic Medical College, India. Complete Peer review History: https://www.sdiarticle4.com/review-history/72814 Received 13 June 2021 Accepted 20 August 2021 Published 01 September 2021 ABSTRACT Introduction: Dental materials whenever used for restorations in the oral cavity can be subjected to dental erosion because of the gastric juices and can cause roughness and act as a nidus for the growth plaque. Aim of this study was to evaluate impact of artificial gastric acid on surface roughness of dental restorations, examining scientific studies published from 2010-2020. Materials and Methods: This study follows and complies with principles of PRISMA guidelines for a systematic review research methodology. In March 2020, an initial search was carried out in the MEDLINE (PubMed), Science Direct, Google Scholar, and Saudi Digital Library database of indexed journals from 2010-2020 using the keywords: impact,” “effect,” “gastric acid,” “gastric juice,” “indirect restorations,” “dental materials,” “dental ceramics,” “crowns,”. Bibliographic materials from these articles were then utilized to find other sources. Results: The MEDLINE (PubMed) search retrieved thirty articles, of which three were relevant to the study. Total articles found in Google scholar were 11,500 article, in which 11 were analyzed for Systematic Review