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Blackwell Publishing Ltd Oxford, UK IJD International Journal of Dermatology 0011-9059 1365-4632 © 2008 The International Society of Dermatology XXX
Correspondence
Correspondence Correspondence
Vulvovaginal-gingival lichen planus – a rare
or underreported syndrome?
We report a patient with vulvovaginal-gingival lichen planus
(VVG-LP), a condition that is difficult to treat and is often
underreported. Ideally, VVG-LP should be diagnosed before
complications start to appear, as they present great morbidity
and are very difficult to treat.
1
A 44-year-old white woman presented with a history of
progressive manifestation, over a 1-year period, of cutaneous
lesions on the hands, feet, and nails, hair loss, and erosions on
the gingiva, tongue, and vulva. The lesions caused itching and
pain. Over the last 3 years, she had experienced an irregular
menstrual cycle, with long periods of amenorrhea, and
complained of dyspareunia and postcoital bleeding. She
was not using any form of contraception. The lesions on the
palms and soles were erythematous and desquamative plaques
with fissures, and the nails were dystrophic with anonychia
(Fig. 1a). On the scalp, there were areas of scarring alopecia.
She showed atrophic-erosive glossitis (Fig. 1b) and erosions
on the gingiva and palate. Whilst examining the vulva, erosive
mucous lesions were noted (Fig. 1c).
Antinuclear antibody (ANA), anti-La, anti-Ro, and anti-
DNA tests were negative. The follicle-stimulating hormone
(FSH), luteinizing hormone (LH), prolactin, and estradiol
levels were normal. At the gynecologic examination, it was
impossible to progress with the device into the vagina because
of the presence of adhesions. Pelvic ultrasound was performed
and found to be normal. The histopathologic examination of
the scalp lesion showed a diffuse, band-like, lymphocytic
infiltrate in the dermis (Fig. 2). Similar aspects were seen for
the erosive tongue lesion (Fig. 2). Direct immunofluorescence
showed subepidermal immunoglobulin M (IgM), IgG, C3,
and fibrin deposition. Erosive LP was diagnosed.
The patient was treated initially with clobetasol proprionate
0.05% solution for the oral lesions and oral prednisone 1 mg / kg
for 2 months, with a partial clinical response. Subsequently,
Figure 1 (a) Dystrophic nails and
anonychia. (b) Atrophic erosive glossitis.
(c) Red erosions and erythema in the labia
minora
International Journal of Dermatology 2009, 48, 322–324 © 2009 The International Society of Dermatology