Preeclampsia is associated with impaired regulation of the placental nitric oxide-cGMP pathway by CRH and CRH-related peptides Emmanouil Karteris 1 , Manu Vatish 2 , Edward W Hillhouse 3 , Dimitris K Grammatopoulos 1,2 1 Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK; 2 Division of Clinical Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL; 3 The Leeds Institute of Health, Genetics and Therapeutics, University of Leeds, Leeds, LS2 9NL, UK, Short title: CRH and placental NO/cGMP regulation in pre-eclampsia Key words: CRH, urocortin II, CRH receptor, pregnancy, pre-eclampsia Corresponding author: Dr D. Grammatopoulos Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. Tele: +44 2476 524 206 Fax: +44 2476 574637 email: d.grammatopoulos@warwick.ac.uk Journal of Clinical Endocrinology & Metabolism. First published March 22, 2005 as doi:10.1210/jc.2004-2210 Copyright (C) 2005 by The Endocrine Society