electrophysiology, brain/behaviour correlations, and focal and global hemodynamics). Finally, this article discusses three possible neural mechanisms for reorganisation, drawing on the best literature from human and animal research.. The chapter on cognitive de®cits is written with a less compelling style. These authors elected to survey the types of de®cits that occur following stroke, and to discuss recovery in more traditional terms (i.e. lesion size, epidemiological predictors). There is some discussion of more neurobiological factors, but this is limited, and overall the presentation reads a bit like a tabulation of information. In fact, some of this text would have been better presented in tabular form. A chapter on mood disorders begins with an overview of mood disorders and assessment scales as they relate to illness in general, and proceeds to a more focused discussion of stroke-related processes. This overall discussion of mood disorders, and of post-stroke depression, in particular, is very well-thought out, and balances several competing theories and notions with a rationed style and pertinent references (e.g. attempts to relate post-stroke depression to particular focal lesions over others). Also adequately presented is the relationship between depression and other stroke manifest- ations, suggesting that depression exacerbates cognitive (p. 202) and motor (p. 204) outcomes. The article also points out the important relationship between depression and anxiety after stroke. An informative short chapter on vascular dementia follows and is clearly written, emphasizing the different types of dementia that are associated with vascular disease, risk factors, the dif®culty in diagnosing vascular dementia, and the controversy surrounding the existence of `pure' vascular dementia (extremely uncommon in autopsy studies). A chapter on pharmacological therapies discusses ongoing research in growth factors, catecholaminergic compounds, and cell-based approaches to the treatment of post-acute stroke. Although such research is critical to the future of neurobiologically based therapies for stroke, this discussion focuses only on agents and effects, without any regard to mechanisms. This represents an important missed opportun- ity, since a detailed section of such an article describing rationales for biological intervention could be exceptionally valuable. The ®nal two chapters of the book are mislocated in the volume. One discusses the economic impact of stroke, and ®ts in naturally in the ®rst section on epidemiology and outcomes. The ®nal chapter of the book addresses an important topic in stroke neurorehabilitation, namely sphincter disturbances. Such a chapter exists in most rehabilitation textbooks, and this relates to the critical importance of urinary and bowel continence in quality of life of stroke patients. This chapter does a good job of presenting both the neurobiology of sphincter control, and the clinical aspects of its dysfunction from stroke. A related topic is control of oral-motor function, also involving a complex neuroanatomy and physiology, and also understudied by neurologists. This topic is not addressed in this book. In summary, this book deals with an important and contemporary issue in stroke recovery, and one that has been neglected by clinical and basic neuroscientists for too long: post-acute stroke treatment. As such, this volume can represent a good introduction to these issues for neurologists who care for patients with stroke. On the other hand, in several respects, this book represents a missed opportunity. The book does a reasonable job of surveying typical neurological topics regarding long-term effects of strokeÐ signs and symptoms, prognosis, secondary prevention, treat- ment of complications, and costs. The chapter on quality of life is particularly well done. On the other hand, modern clinical and basic research in neurobiology has led to a new model for the neurology of stroke, in which acute and post- acute stroke are viewed as the continuum of a single illness, and one for which the clinical goal should be one of cure, rather than of palliation. Without sacri®cing any of the valuable perspectives from the current clinical model, this book could have framed the discussion from the new vantage point. Such an approach to post-acute stroke would emphasize issues (now commonly discussed in the context of acute stroke) of physiological and pharmacological mechanisms of recovery, and the attempt to tie our present knowledge with future goals. The chapter on motor stroke recovery does this very well, and the well-written chapter on mood disorders accomplishes this to a degree. Overall, the book is quite heterogeneous, and consequently, it is easy to recommend certain chapters, but more dif®cult to advocate reading it from cover to cover. S. L. Small and A. Solodkin Neurology and Brain Research Imaging Center, University of Chicago, Chicago, IL, USA DOI: 10.1093/brain/awg095 HEADACHE AND MIGRAINE IN CHILDHOOD AND ADOLESCENCE By V. Guidetti, G. Russell, M. Sillanpaa and P. Winner 2002. Andover: ITPS Price £75. ISBN 1853178101 Paediatricians, general practitioners, neurologists, physicians and many other health care workers deal with headaches in children and adolescents and are aware of the unique challenges involved in their care. A synthesis of the current state of knowledge on this subject is welcome. Such a book offers the useful prospect of a thorough analysis of contem- porary management options. It provides a chance to address some of the intriguing questions faced by cliniciansÐsuch as why younger people get abdominal migraine, why headaches in younger children are often so brief, and what we can advice patients and their families about their prognosis. Book reviews 1243 Downloaded from https://academic.oup.com/brain/article-abstract/126/5/1243/489182 by guest on 17 June 2020